- Unyango
- Ubungqina
- I-Neuroblastoma
- Ithumba Eliqinileyo
- Ubungqina
- Ii-TILS
- Unyango lweeSeli zeNK
- I-Myasthenia Gravis (MG)
- I-Acute Lymphoblastic Leukemia (B-ALL)
- I-Systemic Lupus Erythematosus (SLE)
- I-Acute Lymphoblastic Leukemia (T-ALL)
- I-NonHodgkin Lymphoma (NHL)
- I-Multiple Myeloma（MM）
- Ukusasaza i-B-cell Lymphom enkulu
- I-B-lymphocytic Leukemia
- I-Myeloma
Ukusasaza i-lymphoma enkulu ye-B-cell (DLBCL)-04
UMnu. Li, oneminyaka engama-64 ubudala (igama elingelolokwenyani), wafunyaniswa ene-diffuse large B-cell lymphoma (DLBCL) kwiminyaka emine eyadlulayo, eyayisele ifikelele kwinqanaba lokugqibela lokubandakanyeka kwe-spleen, iimbambo, imiphunga, kunye ne-pleura, ebekwe njengenqanaba lesi-IV. Emva konyango lwe-immunochemotherapy yomgca wokuqala, imeko yakhe yahlala ilungile kangangeminyaka engaphezu kwemithathu. Nangona kunjalo, ngoMatshi wonyaka ophelileyo, isifo sakhe saphinda sabuya, sabandakanya ii-lymph nodes ezininzi ze-retroperitoneal. Nangona i-chemotherapy yomgca wesibini yokusindisa, wafumana kuphela ukuxolelwa okungaphelelanga kwaye yawohloka ngokukhawuleza, kwanyanzeleka unyango olusebenzayo ngakumbi ukulawula ukuqhubela phambili.
Lijongene nalo mceli mngeni unzima, iqela leengcali kwi-BIOOCUS Medical Group lihlolisise ngokubanzi ityala likaMnu. Li laza labiza intlanganiso yeqela elinamacandelo amaninzi (MDT) ukuze licebise unyango lweeseli ze-CAR-T. Unyango lweeseli ze-CAR-T, njengohlobo lwamva nje lwe-tumor immunotherapy, lubonelela ngeenzuzo ezibalulekileyo ezifana nokujolisa ngamandla kunye nokusebenza kakuhle okuhlala ixesha elide kwizigulana ezine-relapse and refractory lymphoma.
NgoJanuwari 2023, uMnu. Li wenziwa unyango lweeseli ze-CAR-T kwiSebe leLymphoma. Ngaphambi kokuba afumane unyango, wenziwa i-biopsy yee-lymph nodes zasekunene ze-inguinal, nto leyo eyaqinisekisa ukuba i-CD19 kunye ne-CD20 zilungile, nto leyo eyanika iinjongo ezicacileyo zonyango lweeseli ze-CAR-T. Phantsi kwesikhokelo sikaNjingalwazi uLi, iqela lezonyango lenza isicwangciso sonyango esilungiselelwe umntu ngamnye.
Ngomhla wama-25 kuJulayi, ngo-2023, uMnu. Li wagqiba inkqubo yokufakwa kweeseli ze-CD19/20 CAR-T, eyaqhubeka kakuhle phantsi kweliso elibukhali leqela lezonyango. Nangona wayene-cytokine release syndrome, i-cytopenia, kunye nomngcipheko wosulelo emva kokufakwa, ukhathalelo oluqinileyo oluxhasayo luye lwalawula ngempumelelo iimpendulo ezingalunganga ngexesha lonyango.
Emva kweenyanga ezintandathu eqalise unyango lweeseli zeCAR-T, uMnu. Li akazange abonise zizilonda zibalulekileyo emzimbeni wakhe wonke, nto leyo eyabangela ukuba afumane impendulo epheleleyo ye-metabolic (CMR), nto leyo eyazisa ithemba elitsha kwimpilo yakhe. Iqela lezonyango longezelele ngakumbi kwizilonda ezisele zibuyele esibelekweni nge-radiotherapy ukuqinisekisa ukubuyela kwesifo ngokupheleleyo kunye nokuzinza kwexesha elide.
Ngale immunotherapy yeeseli ze-CAR-T, uMnu. Li akaphumelelanga nje kuphela kwimeko yakhe kodwa uphinde wafumana ukuzithemba kunye namandla ebomini. Ityala lakhe linika ithemba elitsha kunye nolwalathiso kwizigulane ze-lymphoma kwaye libonisa amandla kunye nokusebenza kakuhle konyango lweeseli ze-CAR-T ekunyangeni i-refractory lymphoma.
Unyango lweeseli ze-CAR-T, njengonyango olutsha lomhlaza, luguqula iindlela zobomi bezigulana ezine-refractory lymphoma. Phantsi kokhathalelo olucokisekileyo lweqela leengcali kwiSebe leLymphoma, izigulana ezininzi ezifana noMnu. Li zinokulindela uphuculo olukhulu ekusindeni nasekuphuculeni ubomi. Ukujonga phambili, ukuqhubela phambili kunye nokusetyenziswa konyango lweeseli ze-CAR-T kuthembisa amathuba abanzi kunye namathuba kunyango lomhlaza.
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