Nkosikazi Siti ---- Ukusasaza i-B-cell Lymphoma enkulu (DLBCL)

UNksk. Siti, umfazi wase-Indonesia oneminyaka engama-58 ubudala, wafunyaniswa ukuba une-primary drug-resistant follicular lymphoma eyathi kamva yaguquka yaba yi-diffuse large B-cell lymphoma (DLBCL). Nangona wayefumana unyango lomgca wesine, ithumba lakhe laqhubeka nokukhula kwalo, lenza ubunzima obukhulu obuneziphumo zokucinezelwa. Ngelishwa, iingxaki zavela xa wafumana ukopha ebuchotsheni emva kokufumana unyango oludibanisa imithambo, nto leyo eyayenza imeko yakhe ibe nzima ngakumbi.

Ngenxa yendlela isifo sakhe esasisihlasela ngayo kunye neendlela zonyango ezimbalwa ezazikho, uNksk. Siti wabhaliswa kuvavanyo lweklinikhi lonyango lweeseli ze-CD19+22 CAR-T emva kweenkqubo ezifunekayo zonyango lwangaphambi konyango. Nangona kunjalo, uvavanyo lokuqala ngoSuku lwe-7 lwabonisa ukwanda okuncinci kweeseli ze-CAR-T, nto leyo ebonisa ukungabikho kokusebenza kakuhle konyango. Uvavanyo olulandelayo ngoSuku lwe-14 kunye noSuku lwama-21 lwabonisa uphuculo oluthe ngcembe, kodwa unyango aluzange lufezekise ukusebenza okufunekayo.

Kuyo yonke indlela yakhe yonyango, ukuqina nokuzimisela kukaNksk. Siti kwakhanya kakhulu. Nangona wayejongene nemiqobo emininzi, wajongana nomngeni ngamnye ngenkalipho engagungqiyo nethemba. Njengoko uvavanyo lwezonyango lwaluqhubeka, iqela lezonyango lalijonga ngokusondeleyo impendulo kaNksk. Siti kunyango. Balungisa indlela yonyango njengoko yayifuneka, beqinisekisa ukuba ufumana unyango olungcono kakhulu oluhambelana neemfuno zakhe. Nangona kwakukho iingxaki zokuqala, ukuphuculwa kancinci kancinci kokwandiswa kweeseli zeCAR-T kwanika ithemba lesiphumo esihle.

Ngomhla wama-28, xa uNksk. Siti wafumana impendulo enzima yomzimba, iqela lezonyango laqalisa ukusebenza, lalawula ngokukhawuleza i-cytokine release syndrome laza lanika uncedo olufunekayo. Ubuchule babo kunye nokungenelela kwabo ngokukhawuleza kwaba negalelo elikhulu ekuzinziseni imeko yakhe kunye nokuvula indlela yenkqubela phambili.

Ngomhla wama-35, impumelelo emangalisayo yokukhululwa kwesi sifo yayibubungqina bokuqina kukaNksk. Siti kunye nemizamo edibeneyo yeqela lezonyango. Uhambo lwakhe aluzange lubonise kuphela amandla onyango lweeseli zeCAR-T kodwa lukwagxininise ukubaluleka kokunyamezela kunye nokhathalelo lomntu ngamnye ekusingatheni iimeko ezinzima zonyango.

UNkskz. Siti uvakalise umbulelo wakhe ngenkathalo yobubele ayifumeneyo, egxininisa impembelelo yenkxaso yeqela lezonyango kuhambo lwakhe lokuchacha. "Ndibulela kakhulu ngokuzinikela nobuchule beqela lam lezonyango," utshilo. "Inkxaso yabo engagungqiyo yandinika amandla ngamaxesha anzima, kwaye ndihlala ndibulela ngokuzinikela kwabo kwimpilo-ntle yam."

Ityala likaNkskz. Siti lisebenza njengomzekelo okhuthazayo wokuqina nethemba xa ujongene nobunzima. Iziphumo zakhe eziphumeleleyo zigxininisa amandla okuguqula iindlela zonyango ezintsha kunye nendima ebalulekileyo yonyango lomntu ngamnye ekuphuculeni iziphumo zesigulana.