Whaea Siti ---- Lymphoma Pūtau-B Nui Marara (DLBCL)

I kitea a Whaea Siti, he wahine Initonīhia, 58 tau te pakeke, he mate pukupuku lymphoma ātete-rongoa tuatahi, ā, i muri mai ka huri hei mate pukupuku lymphoma pūtau-B nui horapa (DLBCL). Ahakoa i whiwhi i te maimoatanga raina tuawhā, i mau tonu tana pukupuku ki te tipu, ka hanga he puranga nui me ngā pānga pēhi. Engari, i puta mai ngā raruraru i te wā i pāngia ai ia e te toto toto i roto i te roro i muri i te whiwhinga i te maimoatanga piriti, ka nui ake te uaua o tōna āhua.

I te mea he kaha te mate, me te iti o ngā kōwhiringa maimoatanga e wātea ana, i whakaurua a Whaea Siti ki tētahi whakamātautau haumanu mō te whakaora pūtau CD19+22 CAR-T whai muri i ngā tikanga maimoatanga i mua i te wā. Heoi, i whakaatuhia e ngā aromatawai tuatahi i te Rā 7 he iti noa te whakanui ake o ngā pūtau CAR-T, e kī ana he koretake te whai huatanga o te rongoā. I whakaatuhia e ngā aromatawai i muri mai i te Rā 14 me te Rā 21 he whakapainga haere, engari kāore i tutuki i te maimoatanga te whai huatanga e hiahiatia ana.

I roto i tana haerenga maimoatanga, i tiaho mai te manawanui me te whakapau kaha o Whaea Siti. Ahakoa ngā arai maha i pā ki a ia, i whakatata atu ia ki ia wero me te maia me te hihiri pumau. I te haere tonu o te whakamātautau haumanu, i aro turukihia e te tīma hauora te urupare a Whaea Siti ki te maimoatanga. I whakarerekētia e rātou te huarahi rongoā i runga i te hiahia, me te whakarite kia whiwhi ia i te tiaki pai rawa atu i whakaritea ki ōna ake hiahia. Ahakoa ngā ngoikoretanga tuatahi, ko te whakapainga haere o te whakanui pūtau CAR-T i homai he hihi o te tumanako mō te putanga pai.

I te Rā 28, i te wā i pāngia ai a Whaea Siti e te kaha o te urupare ārai mate, ka tere te mahi a te tīma hauora, ka whakahaere wawe i te mate tukunga cytokine me te whakarato i te tiaki tautoko e tika ana. Nā tō rātou tohungatanga me te wawaotanga tere i whakatau i tōna āhua me te whakatakoto i te ara mō ngā whanaketanga tonu.

I te Rā 35, ko te whakatutukitanga whakamiharo o te whakaoranga he tohu i te manawanui o Whaea Siti me ngā mahi tahi a te tīma hauora. Kāore i te whakaatu noa i te kaha o te rongoā pūtau CAR-T i roto i tana haerenga, engari i whakanui anō hoki i te hiranga o te manawanui me te tiaki whaiaro i roto i te whakatere i ngā āhuatanga hauora uaua.

I whakapuaki a Whaea Siti i tōna whakawhetai mō te manaakitanga aroha i whakawhiwhia ki a ia, me te whakanui i te pānga o te tautoko a te tīma hauora i tana haerenga ki te whakaoranga. "E tino mihi ana ahau mō te whakapau kaha me te tohungatanga o taku tīma hauora," tana kī. "Nā tā rātou tautoko pumau i whakakaha i ahau i ngā wā tino uaua, ā, e mihi tonu ana ahau mō tā rātou whakapau kaha ki tōku oranga."

He tauira whakahihiri te take a Whaea Siti mō te manawanui me te tumanako i te aroaro o ngā raruraru. E whakaatu ana tana angitu i te kaha whakarerekētanga o ngā maimoatanga auaha me te tūranga nui o te rongoā whaiaro ki te whakapai ake i ngā putanga o ngā tūroro.