Mai Siti ---- Kupararira kweB-cell Lymphoma (DLBCL)

Mai Siti, mukadzi wekuIndonesia ane makore 58 okuberekwa, akaonekwa aine chirwere cheprimary drug-resistant follicular lymphoma icho chakazoshanduka kuita diffuse large B-cell lymphoma (DLBCL). Kunyangwe akarapwa nenzira yechina, bundu rake rakaramba richikura, richiumba bundu rakakura rine simba rekudzvanya. Zvinosuwisa kuti matambudziko akaitika paakabuda ropa muuropi mushure mekurapwa, zvikaita kuti dambudziko rake riwedzere kuoma.

Zvichienderana nekuti chirwere chavo chakanyanya sei uye nzira shoma dzekurapa dzaivapo, Mai Siti vakanyoreswa mukuyedzwa kwekiriniki kweCD19+22 CAR-T cell therapy vachitevera nzira dzinodiwa dzekurapa vasati vatanga. Zvisinei, ongororo dzekutanga paZuva rechinomwe dzakaratidza kuwedzera kushoma kwemasero eCAR-T, zvichiratidza kushomeka kwekushanda kwekurapa. Ongororo dzakatevera paZuva rechi14 neZuva rechi21 dzakaratidza kuvandudzika zvishoma nezvishoma, asi kurapwa kwacho kwakakundikana kuwana kushanda kwaidiwa.

Murwendo rwavo rwekurapwa, kushinga kwaMai Siti uye kutsunga kwavo kwaipenya zvakajeka. Pasinei nekusangana nezvipingamupinyi zvakawanda, vakasangana nedambudziko rega rega neushingi husingazununguki uye tariro. Sezvo kuyedzwa kwekiriniki kwaifambira mberi, timu yezvekurapa yakatarisa zvakanyanya maitiro aMai Siti pakurapwa. Vakagadzirisa nzira yekurapa sezvaidiwa, vachiona kuti vakagamuchira rubatsiro rwakanakisisa rwakakodzera zvavanoda. Pasinei nekukundikana kwekutanga, kuvandudzika zvishoma nezvishoma mukuwedzera kwemasero eCAR-T kwakapa tariro yemhedzisiro yakanaka.

PaZuva rechi28, apo Mai Siti vakanzwa kushushikana kwakanyanya kwemuviri, timu yezvekurapa yakakurumidza kubata chirwere che cytokine release syndrome nekupa rubatsiro rwakakosha. Hunyanzvi hwavo nekupindira kwavo nekukurumidza zvakabatsira mukudzikamisa mamiriro avo ezvinhu uye kugadzira nzira yekufambira mberi.

Pakazosvika Zuva rechi35, kubudirira kukuru kwekuregererwa kwechirwere kwaive humbowo hwekutsungirira kwaMai Siti uye kushanda pamwe chete kwechikwata chekurapa. Rwendo rwavo haruna kungoratidza chete kugona kweCAR-T cell therapy asiwo rwakasimbisa kukosha kwekutsungirira uye kutarisirwa kwemunhu oga mukurarama nemamiriro ezvinhu akaomarara ehutano.

Mai Siti vakaratidza kutenda kwavo nekuda kwetsitsi dzavakapihwa, vachisimbisa kukosha kwerutsigiro rwechikwata chevanachiremba parwendo rwavo rwekupora. "Ndinotenda zvikuru nekuzvipira uye hunyanzvi hwechikwata changu chevanachiremba," vakadaro. "Rutsigiro rwavo rusingaperi rwakandipa simba munguva dzakaoma, uye ndinogara ndichionga kuzvipira kwavo kuhupenyu hwangu."

Nyaya yaMai Siti inoshanda semuenzaniso unokurudzira wekutsungirira netariro mukutarisana nematambudziko. Kubudirira kwavo kunoratidza kugona kwekuchinja kwemishonga mitsva uye basa rinokosha remishonga yakagadzirirwa munhu mumwe nemumwe mukuvandudza mhedzisiro yemurwere.