Acute Lymphoblastic Leukemia (B-ALL)

Murwere ane makore makumi matanhatu nerimwe ekuberekwa wekuSyria ari kurwisana nechirwere cheacute lymphoblastic leukemia (ALL) akawana mukana mutsva wekurarama kuburikidza nekurapa kweCAR-T, pamwe chete neBIOOCUS, iyo yakapa mushonga weCAR-T waishandiswa mukurapwa kwake.

Mohammed, mwanakomana wemurwere uyu, akarondedzera rwendo rurefu rwaamai vake nechirwere cheleukemia. Akaonekwa aine chirwere cheALL muna 2012, amai vake vakatanga kurapwa nechemotherapy uye vakazorora kwemakore mashanu. Zvinosuwisa kuti chirwere chavo chakadzokazve muna 2018, zvikaita kuti vapihwe imwe chemotherapy uye kuisirwa muropa remapfupa e allogeneic. Zvisinei, mushure memwedzi mitanhatu vaisirwa muropa, leukemia yakadzoka zvakare, uye mamwe chemotherapy akanga asisakwanisike. Mhuri iyi yakatsvaga dzimwe nzira dzekurapa asi yakatarisana nematambudziko muSyria, uko mishonga yepamusoro yakaita seCAR-T yakanga isipo.

Mushure mekutsvagurudza kwakadzama, Mohammed akawana kuti China ndiyo yaive pamberi pekurapa kweCAR-T uye kuti chipatara chakarapa varwere vanopfuura 500 nekubudirira kwakanyanya, kunyanya kune ALL, zvichiratidza kuti huwandu hwevarwere vanorerukirwa hunopfuura 90%. Achikurudzirwa nenhamba idzi, Mohammed akaronga kuti amai vake varapwe kuLu Daopei Hospital.

Pavakasvika kuChina, vanachiremba vakaona kuti murwere uyu aive negomarara rakawanda re80% mumongo wake wemapfupa, zvichimuisa muboka remurwere ane njodzi huru. Pasinei nematambudziko aya, timu yezvekurapa muchipatara, Dr. Song, yakatanga kurapwa vachishandisa masero eCAR-T anopiwa neBIOOCUS, iyo inonyanya kuendesa zvigadzirwa zveCAR-T zvemazuva ano kuzvipatara pasi rese.

Mushure memazuva gumi nemashanu chete ekurapwa neCAR-T, pamwe chete nechemotherapy, murwere akasvika pakureruka zvakakwana. Zvakabuda muongororo yake zvakaratidza kuti haana MRD, zvichireva kuti hapana masero eleukemia akaonekwa akasara. Mohammed akaratidza kutenda kukuru nekuda kwemhedzisiro yacho, achiti, "Chishamiso. Chemotherapy kana chero imwe immunotherapy ingadai isina kupa mhedzisiro yakafanana. Kurapwa neCAR-T kwakaponesa hupenyu hwaamai vangu."

Akarumbidzawo timu yeBIOOCUS Medical group achiti, "Vanachiremba nevashandi, kunyanya avo vekuInternational Center, vaive nehunyanzvi uye vakanyatsoteerera. Havana kungopa rubatsiro rwepamusoro chete asiwo rutsigiro rwepfungwa mukati merwendo urwu rwakaoma."

Nyaya iyi inoratidza simba rekurapa kweCAR-T mukurapa varwere VESE vane njodzi huru, kunyanya avo vakakundikana kurapwa kwechinyakare. NeBIOOCUS semubatsiri akavimbika mukupa zvigadzirwa zveCAR-T zvemazuva ano, chipatara ichi chinoramba chichitungamira mukupa mishonga inoponesa hupenyu uye kufambira mberi kwekurapa kenza.

Kune varwere vanotambura neALL, CAR-T therapy inopa tariro itsva, kunyangwe mumamiriro ezvinhu akaoma zvikuru. Chipatara cheLu Daopei chinoramba chakazvipira kupa mishonga mitsva uye kuvandudza mhedzisiro yevarwere vane kenza yeropa.