I-Acute Lymphoblastic Leukemia (B-ALL)

Isiguli esineminyaka engu-61 ubudala esivela eSyria esilwa ne-acute lymphoblastic leukemia (ALL) sithole ithuba elisha lokuphila ngokwelashwa kwe-CAR-T, ngokubambisana ne-BIOOCUS, eyanikeza umkhiqizo we-CAR-T osetshenziswa ekwelashweni kwaso.

UMohammed, indodana yesiguli, wabelane ngohambo olude lukanina olune-leukemia. Etholakale enayo yonke i-ALL ngo-2012, unina waqale wasabela ku-chemotherapy futhi walulama iminyaka emihlanu. Ngeshwa, isifo sakhe saphinde sabuya ngo-2018, okwaholela komunye umjikelezo we-chemotherapy kanye nokufakelwa umnkantsha wethambo we-allogeneic. Kodwa-ke, ezinyangeni eziyisithupha ngemva kokufakelwa, i-leukemia yabuya futhi, futhi ukwelashwa okwengeziwe kwe-chemotherapy kwakungaseyona inketho. Umndeni wafuna ezinye izindlela zokwelapha kodwa wabhekana nemikhawulo eSyria, lapho izindlela zokwelapha ezithuthukisiwe ezifana ne-CAR-T zazingekho.

Ngemva kocwaningo olunzulu, uMohammed wathola ukuthi iShayina yayihamba phambili ekwelashweni kwe-CAR-T nokuthi isibhedlela sase siphathe iziguli ezingaphezu kuka-500 ngamazinga aphezulu empumelelo, ikakhulukazi kubo bonke, sinezinga lokuphumula elingaphezu kuka-90%. Ekhuthazwe yilezi zibalo, uMohammed wahlela ukuba unina athole ukwelashwa eSibhedlela iLu Daopei.

Lapho befika eShayina, odokotela bathola ukuthi isiguli sasinomthwalo omkhulu kakhulu wesimila esingu-80% emnkantsheni waso, okwasenza saba yisiguli esisengozini enkulu. Naphezu kwalezi zinselele, ithimba lezokwelapha esibhedlela, uDkt. Song, laqala ukwelashwa kusetshenziswa amaseli e-CAR-T anikezwa yi-BIOOCUS, egxile ekuletheni imikhiqizo ye-CAR-T esezingeni eliphezulu ezibhedlela emhlabeni jikelele.

Ngemva kwezinsuku ezingu-15 nje kuphela zokwelashwa nge-CAR-T, kuhlanganiswe nokwelashwa ngamakhemikhali, isiguli sathola ukuphulukiswa okuphelele. Imiphumela yokuhlolwa kwaso ibonise ukuthi i-MRD ayinayo, okusho ukuthi awekho amangqamuzana e-leukemia atholakalayo asele. UMohammed uzwakalise ukubonga okujulile ngomphumela, ethi, "Kuyisimangaliso. Ukwelashwa ngamakhemikhali noma olunye uhlobo lokwelashwa ngamasosha omzimba bekungeke kulethe umphumela ofanayo. Ukwelashwa nge-CAR-T kusindise impilo kamama."

Uphinde wancoma ithimba le-BIOOCUS Medical group ethi, "Odokotela nabasebenzi, ikakhulukazi labo abase-International Center, babenekhono elikhulu futhi beqaphile. Abazange banikeze nje kuphela ukunakekelwa kwezokwelapha okuphezulu kodwa futhi banikeze nokusekelwa ngokomzwelo kulo lonke lolu hambo olunzima."

Leli cala libonisa amandla okwelashwa kwe-CAR-T ekwelapheni BONKE iziguli ezisengozini enkulu, ikakhulukazi lezo ukwelashwa kwendabuko okuhlulekile kuzo. Njengoba i-BIOOCUS ingumlingani othembekile ekuhlinzekeni ngemikhiqizo ye-CAR-T yesimanje, isibhedlela siyaqhubeka nokuhola ekuletheni izindlela zokwelapha ezisindisa impilo kanye nokuthuthukisa ukwelashwa komdlavuza.

Ezigulini ezilwa ne-ALL, ukwelashwa kwe-CAR-T kunikeza ithemba elisha, ngisho nasezimweni ezinzima kakhulu. Isibhedlela iLu Daopei sisalokhu sizibophezele ekuhlinzekeni ukwelashwa okusha kanye nokuthuthukisa imiphumela yeziguli ezinomdlavuza wegazi.