Te Mate Pūkahukahu Lymphoblastic Whakapeka (B-ALL)

I kitea e tētahi tūroro 61-tau te pakeke nō Hiria e whawhai ana ki te mate pukupuku toto lymphoblastic acute (ALL) tētahi whai wāhitanga hou ki te ora mā te rongoā CAR-T, i te mahi tahi me BIOOCUS, nāna nei i whakarato te hua CAR-T i whakamahia hei rongoā māna.

I kōrero tahi a Mohammed, te tama a te tūroro, mō te haerenga roa o tōna whaea me te mate leukemia. I kitea tōna whaea he ALL i te tau 2012, ā, i te tuatahi ka whakautu tōna whaea ki te chemotherapy, ā, ka mutu te mahi mō ngā tau e rima. Engari, i hoki anō tōna mate i te tau 2018, ā, ka arahina atu ki tētahi atu wāhanga chemotherapy me te whakawhitinga wheua allogeneic. Heoi, i muri i ngā marama e ono i muri i te whakawhitinga, ka hoki anō te leukemia, ā, kāore i taea te whakamahi anō i te chemotherapy. I rapu te whānau i ētahi atu maimoatanga engari i pāngia e ngā herenga i Hiria, i reira kāore i te wātea ngā maimoatanga matatau pēnei i te CAR-T.

Whai muri i te rangahau whānui, i kitea e Mohammed ko Haina te kaihautū o te rongoā CAR-T, ā, neke atu i te 500 ngā tūroro kua rongoatia e taua hōhipera, ā, he teitei ngā reiti angitu, inā koa mō ngā ALL, me te whakamanamana i ngā reiti murunga hara neke atu i te 90%. Nā te whakatenatena a ēnei tatauranga, i whakarite a Mohammed kia whiwhi maimoatanga tōna whaea i te Hōhipera o Lu Daopei.

I te taenga atu ki Haina, i kitea e ngā tākuta he tino nui te taumahatanga o te pukupuku i roto i te hinu wheua o te tūroro, e 80% te nui, ā, i whakarōpūtia ia hei tūroro mōrearea nui. Ahakoa ēnei wero, i tīmata te tīma hauora i te hōhipera, a Tākuta Song, i te maimoatanga mā te whakamahi i ngā pūtau CAR-T i whakaratohia e BIOOCUS, he tohunga ki te tuku hua CAR-T hou ki ngā hōhipera o te ao.

I muri i ngā rā 15 noa iho o te rongoā CAR-T, me te whakapakari tinana, ka tino marino te tūroro. I whakaatuhia e ngā hua o tana whakamātautau he MRD-negative, arā, kāore he pūtau leukemia i kitea i toe. I whakapuaki a Mohammed i te mihi nui mō te putanga, me te kī, "He merekara. Kāore te rongoā chemotherapy, tetahi atu rongoā ārai mate rānei, i rite te hua. Nā te rongoā CAR-T i ora ai tōku whaea."

I mihi anō hoki ia ki te tīma o te rōpū Hauora BIOOCUS, me te kī, "He tino pūkenga, he aro nui hoki ngā tākuta me ngā kaimahi, inā koa ko te hunga i te International Center. Ehara i te mea ko te tiaki hauora taumata teitei anake tā rātou i whakarato, engari ko te tautoko kare ā-roto hoki i roto i tēnei haerenga uaua."

E whakaatu ana tēnei take i te mana o te rongoā CAR-T ki te rongoā i ngā tūroro ALL mōrearea nui, inā koa ko te hunga kāore i angitu ngā maimoatanga tuku iho. I te mea ko BIOOCUS te hoa pono ki te whakarato i ngā hua CAR-T hou, kei te ārahi tonu te hōhipera i te whakarato i ngā rongoā whakaora ora me te whakatairanga i te rongoā mate pukupuku.

Mō ngā tūroro e whawhai ana ki te ALL, ka tukuna e te rongoā CAR-T he tumanako hou, ahakoa i roto i ngā take tino uaua. Kei te whakapau kaha tonu te Hōhipera o Lu Daopei ki te whakarato maimoatanga auaha me te whakapai ake i ngā putanga mō ngā tūroro e pangia ana e te mate pukupuku toto.