Khansa ya m'magazi ya Lymphoblastic (B-ALL)

Wodwala wazaka 61 wochokera ku Syria yemwe akuvutika ndi khansa ya m'magazi (ALL) adapeza mwayi watsopano wa moyo kudzera mu chithandizo cha CAR-T, mogwirizana ndi BIOOCUS, yomwe idapereka mankhwala a CAR-T omwe adagwiritsidwa ntchito pochiza matenda ake.

Mohammed, mwana wa wodwalayo, adagawana ulendo wautali wa amayi ake ndi khansa ya m'magazi. Atapezeka ndi matenda a ALL mu 2012, amayi ake poyamba adayankha chithandizo cha chemotherapy ndipo adachira kwa zaka zisanu. Tsoka ilo, matenda ake adabwereranso mu 2018, zomwe zidapangitsa kuti alandire chithandizo china cha chemotherapy ndi kuikidwa kwa mafupa a allogeneic. Komabe, miyezi isanu ndi umodzi atapatsidwa chithandizo, khansa ya m'magazi idabwereranso, ndipo mankhwala ena a chemotherapy sanalinso njira ina. Banjali linafunafuna njira zina zochiritsira koma linakumana ndi zopinga ku Syria, komwe njira zamakono monga CAR-T sizinapezeke.

Pambuyo pa kafukufuku wambiri, Mohammed adapeza kuti China inali patsogolo pa chithandizo cha CAR-T ndipo chipatalacho chinathandiza odwala oposa 500 omwe anali ndi chiwopsezo chachikulu, makamaka kwa ALL, omwe anali ndi chiwopsezo chopitirira 90%. Atalimbikitsidwa ndi ziwerengerozi, Mohammed adakonza zoti amayi ake akalandire chithandizo ku Lu Daopei Hospital.

Atafika ku China, madokotala adapeza kuti wodwalayo anali ndi vuto lalikulu la chotupa cha 80% m'mafupa ake, zomwe zinamuika m'gulu la odwala omwe ali pachiwopsezo chachikulu. Ngakhale kuti panali mavuto amenewa, gulu lachipatala ku chipatala, Dr. Song, linayamba kulandira chithandizo pogwiritsa ntchito maselo a CAR-T operekedwa ndi BIOOCUS, yomwe imadziwika bwino popereka mankhwala apamwamba a CAR-T kuzipatala padziko lonse lapansi.

Pambuyo pa masiku 15 okha a chithandizo cha CAR-T, pamodzi ndi chemotherapy, wodwalayo anachira kwathunthu. Zotsatira za mayeso ake zinasonyeza kuti MRD-negative, zomwe zikutanthauza kuti palibe maselo a leukemia omwe anapezeka omwe anatsala. Mohammed anayamikira kwambiri zotsatira zake, nati, "Ndi chozizwitsa. Chemotherapy kapena chithandizo china chilichonse cha immunotherapy sichikanapereka zotsatira zomwezo. Chithandizo cha CAR-T chinapulumutsa moyo wa amayi anga."

Anayamikiranso gulu la BIOOCUS Medical group ponena kuti, "Madokotala ndi ogwira ntchito, makamaka omwe ali ku International Center, anali aluso kwambiri komanso osamala. Sanapereke chithandizo chamankhwala chapamwamba kokha komanso chithandizo chamaganizo paulendo wonse wovutawu."

Nkhaniyi ikuwonetsa mphamvu ya chithandizo cha CAR-T pochiza odwala ONSE omwe ali pachiwopsezo chachikulu, makamaka omwe chithandizo chachikhalidwe chalephera. Ndi BIOOCUS ngati mnzawo wodalirika popereka zinthu zamakono za CAR-T, chipatalachi chikupitilizabe kutsogolera popereka mankhwala opulumutsa miyoyo komanso kupititsa patsogolo chithandizo cha khansa.

Kwa odwala omwe akulimbana ndi ALL, chithandizo cha CAR-T chimapereka chiyembekezo chatsopano, ngakhale m'mavuto ovuta kwambiri. Chipatala cha Lu Daopei chikudziperekabe kupereka chithandizo chatsopano komanso kukonza zotsatira za odwala omwe ali ndi khansa ya m'magazi.