Leukemia ikabije ya Lymphoblastic (B-ALL)

Umurwayi w’imyaka 61 ukomoka muri Siriya urwaye kanseri y’amaraso ikabije (ALL) yabonye amahirwe mashya yo kubaho binyuze mu buvuzi bwa CAR-T, ku bufatanye na BIOOCUS, bamuhaye umuti wa CAR-T wakoreshejwe mu kumuvura.

Mohammed, umuhungu w'umurwayi, yasangiye urugendo rurerure rwa nyina n'indwara ya kanseri y'amaraso. Nyuma yo kurwara kanseri y'amaraso mu 2012, nyina yabanje kuvura kanseri y'amaraso maze amara imyaka itanu akira. Ikibabaje ni uko indwara ye yongeye kugaruka mu 2018, bituma yongera guhabwa imiti ya kanseri ndetse no gutera umworera w'amagufwa. Ariko, nyuma y'amezi atandatu aterwa kanseri y'amaraso, kanseri y'amaraso yongeye kugaruka, kandi imiti ya kanseri yongereye ntiyaba ikiri amahitamo. Umuryango washatse ubundi buryo bwo kuvura ariko wahuye n'imbogamizi muri Siriya, aho uburyo bwo kuvura bugezweho nka CAR-T butabonekaga.

Nyuma y’ubushakashatsi bwimbitse, Mohammed yavumbuye ko Ubushinwa bwari ku isonga mu kuvura CAR-T kandi ko ibitaro byavuje abarwayi barenga 500 bafite igipimo cyo gutsinda cyane, cyane cyane kuri ALL, bafite igipimo cyo koroherwa kiri hejuru ya 90%. Atewe inkunga n’iyi mibare, Mohammed yateguye ko nyina avurirwa mu bitaro bya Lu Daopei.

Bakigera mu Bushinwa, abaganga basanze uyu murwayi afite umutwaro munini cyane wa kanseri mu igufwa rye, bamushyira mu cyiciro cy’umurwayi ufite ibyago byinshi. Nubwo hari izi mbogamizi, itsinda ry’abaganga bo mu bitaro, Dr. Song, ryatangije ubuvuzi hakoreshejwe uturemangingo twa CAR-T dutangwa na BIOOCUS, inzobere mu kugeza ibikoresho bya CAR-T ku bitaro ku isi yose.

Nyuma y'iminsi 15 gusa yo kuvurwa na CAR-T, hamwe no kuvura indwara ya chimiotherapie, umurwayi yakize burundu. Ibisubizo by'ibizamini bye byagaragaje ko nta MRD yari ifite, bivuze ko nta turemangingo twa leukemia twashoboraga kugaragara twasigaye. Mohammed yashimiye cyane ibyavuye mu bushakashatsi bwe, agira ati: "Ni igitangaza. Chimiotherapie cyangwa ubundi buryo ubwo aribwo bwose bwo kuvura ubudahangarwa bw'umubiri ntibwari gutanga umusaruro nk'uwo. Ubuvuzi bwa CAR-T bwarokoye ubuzima bwa mama."

Yanashimiye itsinda rya BIOOCUS Medical group agira ati: "Abaganga n'abakozi, cyane cyane abo mu Kigo Mpuzamahanga, bari abahanga kandi bita ku bandi. Ntibatanze ubuvuzi bwo ku rwego rwo hejuru gusa, ahubwo banatanze inkunga y'amarangamutima muri uru rugendo rukomeye."

Uru rubanza rugaragaza imbaraga z'ubuvuzi bwa CAR-T mu kuvura abarwayi BOSE bari mu kaga gakomeye, cyane cyane abo ubuvuzi gakondo bwananiranye. Bitewe na BIOOCUS nk'umufatanyabikorwa wizewe mu gutanga ibikoresho bigezweho bya CAR-T, ibitaro bikomeje kuyobora mu gutanga ubuvuzi burokora ubuzima no guteza imbere ubuvuzi bwa kanseri.

Ku barwayi barwaye kanseri y’amaraso ya ALL, ubuvuzi bwa CAR-T butanga icyizere gishya, ndetse no mu bihe bigoye cyane. Ibitaro bya Lu Daopei bikomeje kwiyemeza gutanga ubuvuzi bushya no kunoza umusaruro ku barwayi ba kanseri y’amaraso.