Junaid----Leukemia ikabije ya B-lymphocytic (B-ALL)

Igerageza rya CAR-T ryo gutera umwongo w'amagufwa rituma indwara ya B-ALL idashobora kwangirika muri BIOOCUS Medical Group.

Mu myaka itanu ishize, Junaid yari umunyeshuri muri Kaminuza y’Ubuganga ya Pakisitani, afite inyota nyinshi yo kuba umuganga. Ariko muri Gicurasi 2014, yasanze afite kanseri y’amaraso ya B-lymphocytic, bituma ahagarika amasomo ye.

Yavuwe mu gace atuyemo mu gihe cy'imyaka irenga ibiri. Muri Mutarama 2018, yongeye kugira ububabare mu magufwa kandi isuzuma ry'umusemburo ryerekanye ko yongeye kurwara. Nyuma y'icyiciro cya kabiri cya chimiotherapie mu bitaro byo muri ako gace, ntiyashoboye koroherwa kandi indwara yari imaze kwiyongera. Binyuze mu gushakisha kuri interineti no ku nama z'abandi barwayi, bahisemo kuza mu kigo cyacu cya CGT kugira ngo bakorerwe igerageza ryo ku rwego rwo hejuru rya CART na BMT.

Ku ya 26 Werurwe 2018, Junaid n'umuryango we baje mu Bushinwa bakirwa mu ishami rishinzwe indwara z'amaraso. Dr yakoze isuzuma ryimbitse rya Junaid. Raporo zagaragaje ko umuvuduko w'amagufwa wari ku kigero cya 69% kandi ko yari afite indwara z'ibihumyo byo mu bihaha. Nyuma yo kuvurwa neza, umurwayi yari ameze neza. Ku ya 24 Mata 2018, Junaid yongeye guhabwa uturemangingo tubiri twa CD19 na CD22 CAR-T. Nyuma y'ibyumweru bibiri, umubare w'uturemangingo tw'amagufwa wari 0. Inseko zagarutse mu muryango wa Junaid. Junaid yagombaga kujyanwa muri BMT kugira ngo atagira indwara.

Ku ya 25 Kamena 2018, Dr w’ishami rya BMT yakoreye Junaid umuvandimwe we BMT. Uwatanze Junaid ni murumuna we. Ku ya 6 Nyakanga, uturemangingo tw’umuterankunga twometse kuri Junaid twongeye gushyirwa muri Junaid, nyuma y’iminsi 17, harangiye gutera uturemangingo tw’amaraso yera maze ava mu cyumba cy’umuterankunga. Nyuma y’iminsi 24, ubwoko bw’umuterankunga we buhuye neza n’ubwoko bw’umuterankunga w’umuterankunga. Isuzuma rya raporo y’umuterankunga w’amagufwa ryagaragaje ko nta kibazo na kimwe gihari, nta ngaruka zabaye hakiri kare zijyanye no gutera uturemangingo. Ku ya 6 Kanama 2018, Junaid yasezerewe mu bitaro maze atangira gukurikirana abarwayi bo hanze.

Umuryango w’amaraso w’Abashinwa ni wo ushyigikira umurwayi cyane. Junaid afite ubwoko bw’amaraso butarimo RH, ari na bwo bwoko bw’amaraso butarimo RH. Yemeye gutanga amaraso ku buntu inshuro nyinshi mu gihe yari mu bitaro. Kuri we, ntabwo bisa nkaho ari ikibazo cyo kubura amaraso, Junaid n’umuryango we barashimira cyane ikigo mpuzamahanga cyakoze ibi byose kuri Junaid. Hagati aho, abakozi b’ikigo mpuzamahanga baherekeje Junaid n’umuryango we kuva aho bagereye kugeza ubu, babafashije mu buzima bwabo bwose kandi bafasha umuryango gutsinda inzitizi z’ururimi.

Igerageza rya CAR-T rihuza BMT n'ikindi gitangaza. Junaid ni umurwayi wa kabiri wongeye kurwara kanseri y'amaraso ya B-lymphocytic acute kandi udashobora gusubira inyuma ukomoka muri Pakisitani wavuwe na CAR-T Bridge BMT. Kuba Junaid yaravuye mu bitaro bya BMT, byongeye kugaragaza ko ibitaro byacu byamenyekanye ku rwego mpuzamahanga kubera ikoranabuhanga rigezweho ryo gutera CAR-T ikiraro.