Junaid----Acute B-lymphocytic Leukemia (B-ALL)

Kuisirwa kweCAR-T clinical trial bridge bone marrow kunoita kuti pave nechirwere cheB-ALL chisingarapike paBIOOCUS Medical Group.

Makore mashanu apfuura, Junaid aive mudzidzi paPakistan Medical University, aine chishuwo chekuva chiremba. Asi muna Chivabvu 2014, akaonekwa aine chirwere cheB-lymphocytic leukaemia uye aifanira kurega zvidzidzo zvake.

Akarapwa munharaunda kwenguva inopfuura makore maviri. Muna Ndira 2018, akatanga kurwadziwa kwemapfupa zvakare uye kuongororwa kwemupfupa kwakaratidza kuti akanga adzoka. Mushure mekemikoro yechipiri yekurapa chemotherapy kuchipatara chemunzvimbo iyoyo, haana kukwanisa kuwana zororo uye chirwere chakanga chaenderera mberi. Kuburikidza nekutsvaga paindaneti uye kurudziro yevamwe varwere, vakasarudza kuuya kunzvimbo yedu yeCGT kuti vazoongororwa CART Clinical Test neBMT.

Musi wa26 Kurume 2018, Junaid nemhuri yake vakauya kuChina vakapinzwa mubazi rezveropa. Dr vakaongorora Junaid zvakakwana. Mishumo yakaratidza kuti huwandu hwemapfupa emumaronda hwakakwira kusvika 69% uye aive nehutachiona hwefungus hwemapapu. Mushure mekurapwa nekungwarira, murwere aive mumamiriro ezvinhu akagadzikana. Musi wa24 Kubvumbi 2018, Junaid akadzorerwazve nemasero maviri eCD19 neCD22 CAR-T. Mushure memavhiki maviri, huwandu hwemasero emapfupa emumaronda hwakanga huri 0. Kunyemwerera kwakadzokera kumhuri yaJunaid. Junaid aifanira kuvhiyiwa BMT kuti asave nechirwere.

Musi wa25 Chikumi 2018, chiremba weBMT akaita BMT kuna Junaid. Mupi waJunaid munin'ina wake mudiki. Musi wa6 Chikunguru, cell remupi rakadzoserwa kuna Junaid, mushure memazuva gumi nemanomwe, kuiswa kwemasero machena eropa kwapera uye akatama kubva muwadhi yekuyerera kweropa. Mushure memazuva makumi maviri nemana, mhando yemapfupa ake emupfupa yakaenzana zvachose nerudzi rwemapfupa emupfupa. Ongororo yemushumo wemapfupa emupfupa haina kunaka, pasina matambudziko ekutanga ane chekuita nekuisirwa. Musi wa6 Nyamavhuvhu 2018, Junaid akabudiswa muchipatara ndokutanga kuteverwa nevarwere vasiri muchipatara.

Sangano reropa rekuChina ndiro rutsigiro rwakasimba rwemurwere. Junaid ane ropa risina RH, iro riri rudzi rweropa rusingawanzoitiki. Akabvuma kupa ropa mahara kakawanda panguva yaaiva muchipatara. Kwaari hazviratidzike sekushaikwa kweropa, Junaid nemhuri yake vanoonga zvikuru sangano repasi rose nekuita zvese izvi kuna Junaid. Panguva iyi, vashandi vesangano repasi rose vakaperekedza Junaid nemhuri yake kubva pavakasvika kusvika pari zvino, vakavapa rutsigiro rwehupenyu uye vakabatsira mhuri kukunda dambudziko remutauro.

Kuedzwa kwekiriniki yeCAR-T kunoita kuti BMT ibudirire uye iite chimwe chishamiso. Junaid ndiye murwere wechipiri ane B-lymphocytic leukaemia acute reincarnated uye refractory anobva kuPakistan anowana kurapwa kweCAR-T Bridge BMT. Kubuda kwaJunaid muchipatara kwaratidza zvakare kuzivikanwa kwenyika dzese kwehunyanzvi hwepamusoro hwechipatara chedu hwekuisirwa bhiriji reCAR-T.