- Kurapa
- Uchapupu
- Neuroblastoma
- Gomarara Rakasimba
- Uchapupu
- TILS
- Kurapa Masero eNK
- Myasthenia Gravis (MG)
- Acute Lymphoblastic Leukemia (B-ALL)
- Systemic Lupus Erythematosus (SLE)
- Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)
- Non Hodgkin Lymphoma (NHL)
- Multiple Myeloma (MM)
- Kuparadzira Lymphom yeB-cell yakakura
- B-lymphocytic Leukemia
- Myeloma
Chirwere cheAcute Lymphoblastic Leukemia (B-ALL)-03
Zvimiro zveNyaya:
- Akaonekwa aine chirwere cheB-cell lymphoblastic leukemia pakupera kwaChivabvu 2020.
- Ropa rekushandisa: WBC 5.14x10^9/L, HGB 101.60g/L, PLT 6x10^9/L.
- Maumbirwo emubofu: Hypocellular ine 67% primitive lymphocytes.
- Flow cytometry: 82.28% yemasero anoratidza CD38, HLA-DR, CD19, CD10, CD105, TDT, CD22, cCD79a, CD9 inoratidza zvishoma, CD13 inoratidza zvishoma.
- Kuongororwa kwemajini eFusion hakuna kunaka; WT1 57.3%; hapana majini efusion ane chekuita nePH akafanana neeALL akawanikwa.
- HOVE: TP53 shanduko yakanaka.
- Machromosome: 63-58, XXY, +Y, +1, +del(1)(q41q42), -2, -3, +6, -7, +8, -9, +10, -12, -13, +14, +15, -17, +18, -20, +22(cp16)/46, XY[4].
- Ndakagamuchira chirongwa cheVCDLP chezvidzidzo zviviri pasina kuregererwa.
- Chirongwa cheCAM-VL (CTX 2gx2, Arac 200mgx6, 6-MP 100mgx14, VDS 4mgx2, L-ASP 10,000 IUx7) musi wa22 Chikunguru 2020, pasina kuregererwa.
- Kuyerera kwemasero mubope marrow musi wa25 Gunyana, 2020: 7.35% yemasero anoburitsa CD81, CD19, CD10, CD38, CD33, CD20, CD45 zvishoma.
- Kuongorora kuchinja kwegomarara reropa: kuchinja kweTP53.
- Machromosome: 46, XY[20].
- Tatanga kurapwa neCD19-CART.
- Kurapwa kweFC (FLU 62.7mg x mazuva mana, CTX 1045mg x mazuva maviri) chemotherapy.
- Gumiguru 1, 2020: Kuiswa kwemasero eCD19-CART eAutologous pa 4.7x10^7/kg.
- CRS giredhi rechipiri ine chepfu yeuropi yegiredhi rekutanga, yakagadziridzwa mushure mekurapwa nerutsigiro.
- Gumiguru 29, 2020: Kuregererwa kwakakwana muchimiro chemapfupa emubofu, pasina masero ekare anouraya pa flow cytometry.
- Zvita 31, 2020: Kukosora kwakaoma, kuda kurutsa, kurutsa, kushaya simba kwakawanda.
- Ropa rekushandisa: WBC 15.53x10^9/L, HGB 134g/L, PLT 71x10^9/L.
- Kufema kwemapfupa zvichiratidza kudzokera shure.
- Ndira 2, 2021: Ndakapinda muchipatara chedu.
- Ropa rekushandisa: WBC 20.87x10^9/L, HGB 118.30g/L, PLT 58.60x10^9/L.
- Creatinine 134umol/L, chirwere cheBP chedanho rechitatu, nhoroondo yezvekurapa kwemakore mana.
- Kurongwa kweropa rekunze: 62% masero ekutanga.
- Immunophenotyping: 28.48% yemasero (masero ane nucleotides) anoratidza CD10, CD38dim, HLA-DR, CD20dim, CD24, CD81, cCD79a, CD22, CD268dim, CD58, anoratidza zvishoma CD123, TDT, haaratidzi CD34, CD19, MPO, CD117, CD13, CD33, CD11b, clgM, CD79b, CD7, cCD3, kappa, lambda, zvichiratidza malignant primitive B lymphocytes.
- Kuongororwa kwekuchinja kwegomarara reropa: TP53 R196P shanduko yakanaka.
Kurapa:
- Ndakawana VLP chemotherapy, pamwe chete nekurapwa kweBP, kuderedza creatinine, uye alkalinization yemvura mumuviri.
- Ndira 19: Kuongororwa kweropa kwakaratidza kuti WBC 1.77x10^9/L, HGB 71g/L, PLT 29.8x10^9/L.
- Kurongwa kweropa rekunze: Hapana ma lymphocytes ekutanga.
- Maumbirwo emapfupa emubofu: Hypercellularity (giredhi reV), nzvimbo dzakananga dzegiredhi reIV, ne42% yemalymphocytes ekutanga.
- Flow cytometry: 13.91% yemasero anoratidza CD10, cCD79a, CD38, CD81, CD22, haaratidzi CD20, CD34, CD19, zvichiratidza masero eB ekare ane malignant.
- Karyotype yechromosome:
- 35,XY,-2,-3,-4,-5,-7,-9,-12,-13,-16,-17,-20[8]/35,XY,+X,-2,-3,-4,-5,-7,-9,-10,-12,-13,-16,-17,-20[1]/36,XY,wedzera(1)(q42),-2,-3,-4,-7,-9,-12,-13,-16,-17,-20[1]/46,XY[20].
- Ndira 20: Lymphocytes dzakaunganidzwa kuti dzishandiswe pakukura kwemasero eCD22-CART.
- Ndira 21: Kuboorwa kwemusana kwakaitwa, chemotherapy yakapihwa mukati memusana kudzivirira leukemia yetsinga huru; kuongororwa kwemvura yemusana kwakaratidza kuti hapana chakaipa.
- Ndira 22: Ndakawana Arac, 6MP, L-ASP chemotherapy, uye FC (Flu 50mg x 3, CTX 0.5gx 3) chemotherapy.
- Kukadzi 7 (usati waiswa mushonga): Maumbirwo emapfupa emubofu akaratidza 93% emalymphocytes ekutanga.
- Flow cytometry: 76.42% yemasero anoratidza CD38, cCD79a, CD22, cbcl-2, CD123, CD10bri, CD24, CD81, haaratidzi CD4, CD3, CD13+33, CD34, CD20, CD19, CD279 (PD1), CD274 (PDL1), zvichiratidza masero eB ekare ane malignant.
- Kurwara kweganda nenyama dzakapfava kunokonzerwa nefivha; kwakavandudzika mushure mekurapwa nemishonga inorwisa mabhakitiriya.
- Kukadzi 9: Kuiswa kwemasero eCD22-CART eAutologous (5x10^5/kg).
- Migumisiro inokonzerwa neCAR-T: CRS grade 1, fivha pazuva rechitanhatu ine Tmax 40°C, tembiricha inodzorwa pazuva rechi10; hapana chepfu muuropi.
- Kurume 11: Kuongororwa kwemapfupa kwakaratidza kurerukirwa kwakakwana kwechimiro, flow cytometry haina kuratidza masero ekutanga ane malignant.
tsananguro2
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