- Kev Kho Mob
- Cov Lus Pov Thawj
- Neuroblastoma
- Mob qog khov kho
- Cov Lus Pov Thawj
- TILS
- Kev Kho Mob NK Cell
- Myasthenia Gravis (MG)
- Kab mob qog ntshav Lymphoblastic loj heev (B-ALL)
- Kab mob Lupus Erythematosus (SLE)
- Kab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)
- Cov kab mob qog nqaij hlav tsis yog Hodgkin (NHL)
- Ntau yam mob myeloma (MM)
- Diffuse Large B-cell Lymphoma
- Kab mob B-lymphocytic Leukemia
- Mob qog nqaij hlav
Kab mob qog ntshav Lymphoblastic mob hnyav (B-ALL)-03
Cov Nta ntawm Cov Ntaub Ntawv:
- Tau kuaj pom tias muaj mob leukemia B-cell lymphoblastic thaum kawg ntawm lub Tsib Hlis 2020.
- Kev ntsuas ntshav: WBC 5.14x10^9/L, HGB 101.60g/L, PLT 6x10^9/L.
- Cov qauv ntawm cov pob txha hauv pob txha: Hypocellular nrog 67% lymphocytes qub.
- Flow cytometry: 82.28% ntawm cov cell qhia CD38, HLA-DR, CD19, CD10, CD105, TDT, CD22, cCD79a, qhia ib nrab CD9, qhia tsis muaj zog CD13.
- Kev tshuaj xyuas cov noob caj noob ces sib xyaw tsis pom zoo; WT1 57.3%; tsis pom cov noob caj noob ces sib xyaw uas cuam tshuam nrog PH zoo li ALL.
- FISH: TP53 mutation zoo.
- Cov Chromosomes: 63-58, XXY, +Y, +1, +del(1)(q41q42), -2, -3, +6, -7, +8, -9, +10, -12, -13, +14, +15, -17, +18, -20, +22(cp16)/46, XY[4].
- Tau txais kev kho mob VCDLP rau 2 chav kawm yam tsis tau kev zam txim.
- CAM-VL regimen (CTX 2gx2, Arac 200mgx6, 6-MP 100mgx14, VDS 4mgx2, L-ASP 10,000 IUx7) rau lub Xya Hli 22, 2020, tseem tsis tau zoo.
- Kev ntsuas cov ntshav ntws ntawm cov pob txha thaum lub Cuaj Hlis 25, 2020: 7.35% ntawm cov hlwb qhia CD81, CD19, CD10, CD38, CD33, qhia CD20, CD45 tsis muaj zog.
- Kev tshuaj xyuas kev hloov pauv ntawm cov qog ntshav: kev hloov pauv TP53.
- Cov Chromosomes: 46, XY[20].
- Pib kho mob CD19-CART.
- Kev kho mob FC (FLU 62.7mg x 4 hnub, CTX 1045mg x 2 hnub) chemotherapy.
- Lub Kaum Hli 1, 2020: Kev txhaj tshuaj CD19-CART rau hauv lub cev ntawm 4.7x10^7/kg.
- CRS qib 2 nrog qib 1 neurotoxicity, zoo dua tom qab kev kho mob txhawb nqa.
- Lub Kaum Hli Ntuj hnub tim 29, 2020: Kev zam txim tag nrho hauv cov pob txha pob txha morphology, tsis muaj cov hlwb malignant primitive ntawm cov cytometry ntws.
- Lub Kaum Ob Hlis 31, 2020: Hnoos qhuav, xeev siab, ntuav, tsis muaj zog.
- Cov ntshav niaj hnub: WBC 15.53x10^9/L, HGB 134g/L, PLT 71x10^9/L.
- Kev kuaj mob ntawm cov pob txha qhia tias rov qab mob dua.
- Lub Ib Hlis 2, 2021: Tau nkag mus rau hauv peb lub tsev kho mob.
- Cov ntshav niaj hnub: WBC 20.87x10^9/L, HGB 118.30g/L, PLT 58.60x10^9/L.
- Creatinine 134umol/L, ntshav siab theem 3, keeb kwm mob nkeeg 4 xyoos.
- Kev faib tawm cov ntshav ntawm cov hlab ntsha: 62% cov hlwb qub.
- Kev ntsuam xyuas kev tiv thaiv kab mob: 28.48% ntawm cov hlwb (cov hlwb nucleated) qhia tawm CD10, CD38dim, HLA-DR, CD20dim, CD24, CD81, cCD79a, CD22, CD268dim, CD58, qhia tawm ib nrab CD123, TDT, tsis qhia tawm CD34, CD19, MPO, CD117, CD13, CD33, CD11b, clgM, CD79b, CD7, cCD3, kappa, lambda, qhia tias yog malignant primitive B lymphocytes.
- Kev tshuaj xyuas kev hloov pauv ntawm cov qog ntshav: TP53 R196P kev hloov pauv zoo.
Kev Kho Mob:
- Tau txais kev kho mob VLP chemotherapy, nrog rau kev kho mob ntshav siab, kev txo creatinine, thiab hydration alkalinization.
- Lub Ib Hlis 19: Cov ntshav kuaj pom tias muaj WBC 1.77x10^9/L, HGB 71g/L, PLT 29.8x10^9/L.
- Kev faib tawm ntawm cov ntshav ntawm sab nraud: Tsis muaj cov lymphocytes qub.
- Cov qauv ntawm cov pob txha hauv pob txha: Hypercellularity (qib V), cov cheeb tsam tseem ceeb ntawm qib IV, nrog rau 42% cov lymphocytes qub.
- Kev ntsuas cov ntshav ntws: 13.91% ntawm cov hlwb qhia CD10, cCD79a, CD38, CD81, CD22, tsis qhia CD20, CD34, CD19, qhia txog cov hlwb B thawj zaug malignant.
- Cov qauv ntawm cov chromosomes:
- 35,XY,-2,-3,-4,-5,-7,-9,-12,-13,-16,-17,-20[8]/35,XY,+X,-2,-3,-4,-5,-7,-9,-10,-12,-13,-16,-17,-20[1]/36,XY,ntxiv(1)(q42),-2,-3,-4,-7,-9,-12,-13,-16,-17,-20[1]/46,XY[20].
- Lub Ib Hlis 20: Cov Lymphocytes raug sau rau kev cog qoob loo ntawm CD22-CART.
- Lub Ib Hlis 21: Tau muab lub duav puncture, muab tshuaj kho mob rau hauv lub qhov (thecal chemotherapy) los tiv thaiv kab mob leukemia hauv lub paj hlwb; kev kuaj cov kua hauv lub hlwb tsis pom muaj qhov txawv txav.
- Lub Ib Hlis 22: Tau txais Arac, 6MP, L-ASP chemotherapy, thiab FC (Flu 50mg x 3, CTX 0.5gx 3) chemotherapy.
- Lub Ob Hlis 7 (ua ntej txhaj tshuaj): Cov qauv ntawm cov pob txha hauv cov pob txha qhia tau tias muaj 93% ntawm cov lymphocytes qub.
- Flow cytometry: 76.42% ntawm cov hlwb qhia CD38, cCD79a, CD22, cbcl-2, CD123, CD10bri, CD24, CD81, tsis qhia CD4, CD3, CD13+33, CD34, CD20, CD19, CD279 (PD1), CD274 (PDL1), qhia txog cov hlwb B malignant primitive.
- Tau muaj kev kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos nrog rau kub taub hau; zoo dua tom qab kho nrog tshuaj tua kab mob.
- Lub Ob Hlis 9: Kev txhaj tshuaj CD22-CART rau hauv lub hlwb (5x10^5/kg).
- Cov kev mob tshwm sim los ntawm CAR-T: CRS qib 1, kub taub hau rau Hnub 6 nrog Tmax 40°C, tswj tau qhov kub thiab txias rau Hnub 10; tsis muaj tshuaj lom rau lub paj hlwb.
- Lub Peb Hlis 11: Kev ntsuam xyuas cov pob txha qhia tau tias cov morphological relieving tag nrho, flow cytometry qhia tsis muaj cov hlwb malignant primitive.
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