Lymphoma yeB-cell Large Resistant Diffuse (DLBCL) ine mitsetse yakawanda isingaparadzike

VaX, murwere wechirume, vakabatwa nechirwere che multi-line resistant diffuse large B-cell lymphoma (DLBCL), chirwere chinonetsa chinoratidzwa nekusagona kwegomarara kurapwa kwakasiyana-siyana. Pakuongororwa kwekutanga, VaX vakanyunyuta nezvekurwadziwa kwemudumbu, zvikaita kuti pave nekuferefetwa kwakawanda.

Zvidzidzo zvemifananidzo, kusanganisira Mufananidzo 1, zvakaratidza kuti paiva nebundu guru mudumbu, zvichiratidza kuti chirwere chacho chakanyanya kupararira. Kuvapo kwebundu rakadaro hakuna kungobatsira chete kuti VaX vasarware mudumbu asiwo kwakakonzera kunetseka nezvekuenderera mberi kwechirwere chavo chelymphoma.

Tichifunga nezvekubudirira kushoma kwemishonga yekare uye kudiwa kwekukurumidzira kwekupindira kunobudirira, VaX vakanyoreswa mukuyedzwa kwekiriniki kweCD19+22 CAR-T cell therapy. Mushure mekuita matanho ekugadzirira anodiwa, kusanganisira kurapwa kwekutanga, VaX vakapinzwa masero eCD19+22 CAR-T.

Zvinoshamisa kuti, Mufananidzo wechipiri, wakatorwa mwedzi mitatu mushure mekudzorerwa kwemasero eCD19+22 CAR-T, wakaratidza kunyangarika zvachose kwedumbu. Mhinduro iyi inoshamisa pakurapwa yakaratidza mhedzisiro yakabudirira, nekubvisa lymphoma zvinobudirira.

Murwendo rwavo rwekurapwa, VaX vakabatsirwa zvakakwana nechikwata chekurapa. Izvi zvaisanganisira kunyatsoongorora mamiriro avo ezvinhu, kutarisira migumisiro yekurapa, uye rutsigiro rwepfungwa kuti vakwanise kutsungirira matambudziko ekurwisa kenza.

Pamusoro pezvo, kunze kwekutarisirwa kwehutano, takapa VaX mabasa akasiyana-siyana kuti tive nechokwadi chekuti vagara zvakanaka panguva yekurapwa kwavo. Izvi zvaisanganisira kuvagadzirira pekugara pakanaka, kuvapa chikafu chinovaka muviri chakakodzera zvinodiwa zvavo, kuronga zvekufambisa zvekusangana navo uye zvinodiwa pakufamba, uye kuvapa rutsigiro rwepfungwa kwavari nemhuri yavo kuti vavabatsire kufamba munguva ino yakaoma.

Nyaya yaVaX inoratidza mukana wekurapa kwakagadzirwa nemaoko senge CAR-T cell therapy mukukunda DLBCL isingapindi mishonga yakawanda. Izvi zvinoratidza kukosha kwekuenderera mberi nekutsvaga nekuvandudza mune zvekurapa kenza kuti pave netariro uye nzira dzekurapa dzinoshanda kune varwere vari kutarisana negomarara rakaoma kurapa seDLBCL.

Mwedzi mitatu usati wapihwa mushonga weinfusion