- Unyango
- Ubungqina
- I-Neuroblastoma
- Ithumba Eliqinileyo
- Ubungqina
- Ii-TILS
- Unyango lweeSeli zeNK
- I-Myasthenia Gravis (MG)
- I-Acute Lymphoblastic Leukemia (B-ALL)
- I-Systemic Lupus Erythematosus (SLE)
- I-Acute Lymphoblastic Leukemia (T-ALL)
- I-NonHodgkin Lymphoma (NHL)
- I-Multiple Myeloma（MM）
- Ukusasaza i-B-cell Lymphom enkulu
- I-B-lymphocytic Leukemia
- I-Myeloma
I-Lymphoma ye-B-cell enkulu enganyangekiyo kwiindlela ezininzi (i-DLBCL)
UMnu. X, isigulana esiyindoda, wayene-multi-line resistant diffuse large B-cell lymphoma (DLBCL), imeko enzima ebonakaliswa kukuxhathisa kwethumba kwiindlela ezahlukeneyo zonyango. Emva kovavanyo lokuqala, uMnu. X wakhala ngentlungu enkulu yesisu, nto leyo eyabangela ukuba kwenziwe uphando olongezelelekileyo.
Izifundo zomfanekiso, kuquka noMfanekiso 1, zityhile ubunzima obukhulu esiswini, nto leyo ebonisa ukubandakanyeka okukhulu kwesifo. Ukubakho kobunzima obunjalo akuphelelanga nje ekungonwabi kwesisu sikaMnu. X kodwa kwaphakamisa neenkxalabo malunga nokuqhubela phambili kunye nobukhali be-lymphoma yakhe.
Ukuqwalasela impumelelo encinci yeendlela zonyango zangaphambili kunye nesidingo esingxamisekileyo sokungenelela okusebenzayo, uMnu. X wabhaliswa kuvavanyo lweklinikhi lonyango lweeseli ze-CD19+22 CAR-T. Emva kokuthatha amanyathelo okulungiselela ayimfuneko, kuquka unyango lwangaphambi konyango, uMnu. X wafumana ukufakwa kweeseli ze-CD19+22 CAR-T.
Okumangalisayo kukuba, uMfanekiso 2, othathwe emva kweenyanga ezintathu emva kokubuyiselwa kweeseli ze-CD19+22 CAR-T, ubonise ukunyamalala ngokupheleleyo kwesisu. Le mpendulo imangalisayo kunyango ibonise isiphumo esiphumelelayo, kwaye i-lymphoma yapheliswa ngempumelelo.
Kuyo yonke indlela yakhe yonyango, uMnu. X wafumana unyango olupheleleyo kunye nenkxaso kwiqela lezonyango. Oku kuquka ukujonga imeko yakhe ngokusondeleyo, ukulawula iziphumo ebezingalindelekanga ezinxulumene nonyango, kunye nenkxaso yeemvakalelo ukumnceda akwazi ukumelana nemingeni yokulwa nomhlaza.
Ukongeza, ngaphaya konyango, sinike uMnu. X uluhlu lweenkonzo ukuqinisekisa impilo-ntle yakhe ngexesha lonyango lwakhe. Oku kuquka ukumlungiselela indawo yokuhlala ekhululekileyo, ukumnika ukutya okunesondlo okufanela iimfuno zakhe zokutya, ukulungiselela uthutho lweentlanganiso zakhe neemfuno zokuhamba, kunye nokubonelela ngenkxaso yengqondo kuye nakusapho lwakhe ukubanceda badlule kweli xesha linzima.
Ityala likaMnu. X ligxininisa amandla onyango olutsha olufana nonyango lweeseli zeCAR-T ekulweni ne-DLBCL engamelaniyo nemigca emininzi. Ligxininisa ukubaluleka kophando oluqhubekayo kunye nophuhliso kwicandelo le-oncology ukubonelela ngethemba kunye neendlela zonyango ezisebenzayo kwizigulana ezijongene nomhlaza okunzima ukuwunyanga njenge-DLBCL.
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