I-Lymphoma Enkulu Ye-B-cell Engamelani Nemigqa Eminingi (i-DLBCL)

UMnu. X, isiguli sesilisa, utholakale ene-multi-line resistant diffuse large B-cell lymphoma (DLBCL), isimo esiyinselele esibonakala ngokumelana kwesimila nezindlela eziningi zokwelashwa. Lapho ehlolwa okokuqala, uMnu. X wakhononda ngobuhlungu obukhulu besisu, okwabangela uphenyo olwengeziwe.

Izifundo zokuthatha izithombe, okuhlanganisa noMfanekiso 1, zembule inqwaba enkulu esiswini, okubonisa ukubandakanyeka okukhulu kwesifo. Ukuba khona kwenqwaba enjalo akugcini nje ngokubangela ukungakhululeki kwesisu sikaMnu. X kodwa futhi kwaphakamisa ukukhathazeka mayelana nokuqhubeka nolaka lwe-lymphoma yakhe.

Uma kucatshangelwa impumelelo encane yemigqa yokwelapha yangaphambilini kanye nesidingo esiphuthumayo sokungenelela okuphumelelayo, uMnu. X wabhaliswa esivivinyweni somtholampilo sokwelashwa kwamaseli e-CD19+22 CAR-T. Ngemva kokuthatha izinyathelo zokulungiselela ezidingekayo, okuhlanganisa nokwelashwa kwangaphambi kokwelashwa, uMnu. X wathola ukufakwa kwamaseli e-CD19+22 CAR-T.

Ngokuphawulekayo, iSithombe 2, esithathwe ezinyangeni ezintathu ngemuva kokubuyiselwa kwamaseli e-CD19+22 CAR-T, sabonisa ukunyamalala okuphelele kwesisu. Le mpendulo emangalisayo ekwelashweni yabonisa umphumela ophumelelayo, lapho i-lymphoma yaqedwa ngempumelelo.

Kuwo wonke uhambo lwakhe lokwelashwa, uMnu. X wathola ukunakekelwa okuphelele kanye nokusekelwa yithimba lezokwelapha. Lokhu kwakuhlanganisa ukuqapha isimo sakhe eduze, ukuphathwa kwemiphumela emibi ehlobene nokwelashwa, kanye nokusekelwa ngokomzwelo ukuze kumsize abhekane nezinselele zokulwa nomdlavuza.

Ngaphezu kwalokho, ngale kokunakekelwa kwezokwelapha, sinikeze uMnu. X izinsizakalo ezahlukahlukene ukuqinisekisa inhlalakahle yakhe iyonke ngesikhathi sokwelashwa kwakhe. Lokhu kuhlanganisa ukumlungiselela indawo yokuhlala ekhululekile, ukumnika ukudla okunempilo okufanela izidingo zakhe zokudla, ukuhlela izinto zokuhamba zemihlangano yakhe nezidingo zokuhamba, kanye nokunikeza ukwesekwa kwengqondo kuye nomndeni wakhe ukuze kubasize badlule kulesi sikhathi esinzima.

Icala likaMnu. X liqokomisa amandla okwelashwa okusha njengokwelashwa kwamaseli e-CAR-T ekunqobeni i-DLBCL engamelana nemigqa eminingi. Ligcizelela ukubaluleka kocwaningo oluqhubekayo kanye nentuthuko emkhakheni we-oncology ukuze kunikezwe ithemba kanye nezinketho zokwelapha ezisebenzayo ezigulini ezibhekene nomdlavuza okunzima ukwelapha njenge-DLBCL.

Ngaphambi kanye nezinyanga ezi-3 ngemuva kokumnika