Kupararira kweB-cell lymphoma yakakura (DLBCL)-04

VaLi, vane makore makumi matanhatu nemana (zita rekunyepedzera), vakaonekwa vaine chirwere che diffuse large B-cell lymphoma (DLBCL) makore mana apfuura, icho chakanga chasvika padanho rekupedzisira rekubata spleen, mbabvu, mapapu, uye pleura, zvakaiswa muchikamu chechina. Mushure mekurapwa ne immunochemotherapy yekutanga, chirwere chavo chakaramba chiri chidiki kwemakore anopfuura matatu. Zvisinei, munaKurume wegore rapfuura, chirwere chavo chakadzokazve, chinosanganisira multiple retroperitoneal lymph nodes. Pasinei ne second-line salvage chemotherapy, vakangowana kuregererwa kwechikamu uye vakakurumidza kuora, zvichikonzera kurapwa kunoshanda zvakanyanya kudzora kufambira mberi kwechirwere.

Vakatarisana nedambudziko iri rakaoma, timu yenyanzvi kuBIOOCUS Medical Group yakaongorora zvakanyanya nyaya yaVaLi ndokuunganidza musangano wechikwata che multidisciplinary team (MDT) kuti vakurudzire kurapwa kweCAR-T cell. CAR-T cell therapy, senzira yazvino yekurapa tumor immunotherapy, inopa mabhenefiti akakosha akadai sekutarisa kwakasimba uye kushanda kwenguva refu kwevarwere vane relapse and refractory lymphoma.

Muna Ndira 2023, VaLi vakarapwa neCAR-T cell therapy kuLymphoma Department. Vasati varapwa, vakaongororwa right inguinal lymph nodes, izvo zvakasimbisa kuti CD19 neCD20 zvakachengeteka, zvichipa zvinangwa zvakajeka zveCAR-T cell therapy. Vachitungamirirwa naProfessor Li, timu yezvekurapa yakagadzira hurongwa hwekurapa hwakasiyana.

Musi wa25 Chikunguru, 2023, VaLi vakapedza chirongwa chekuisa maCD19/20 CAR-T cells, izvo zvakaenderera mberi zvakanaka pasi pekutariswa kwakanyatsoitwa nechikwata chekurapa. Kunyangwe paine cytokine release syndrome, cytopenia, uye njodzi dzehutachiona mushure mekuisirwa, rubatsiro rwakasimba rwakakwanisa kudzora migumisiro yakaipa panguva yekurapwa.

Mwedzi mitanhatu mushure mekushandisa CAR-T cell therapy, VaLi havana kuratidza maronda akakosha mumuviri wavo wese, zvichiita kuti vawane mhinduro yakakwana yemuviri (CMR), izvo zvakaunza tariro itsva kuhutano hwavo. Chikwata chekurapa chakawedzerazve maronda emudumbu akasara neradiotherapy kuti chive nechokwadi chekuti chirwere chinodzoka shure uye kuti chigare kwenguva refu.

Kuburikidza nekurapwa kweCAR-T cell immunotherapy uku, VaLi havana kungovandudza mamiriro avo ezvinhu chete asiwo vakawanazve chivimbo nehupenyu hwakanaka. Nyaya yavo inopa tariro itsva negwara kune varwere velymphoma uye inoratidza kugona uye kushanda kweCAR-T cell therapy mukurapa refractory lymphoma.

Kurapa nemasero eCAR-T, senzira itsva yekurapa kenza, kuri kushandura mararamiro evarwere vane refractory lymphoma. Vachitarisirwa nenyanzvi dzeLymphoma Department, varwere vakawanda vakaita saVaLi vanogona kutarisira kuvandudzwa kukuru mukurarama uye mhando yehupenyu. Tichitarisa mberi, kufambira mberi nekushandiswa kwekurapa nemasero eCAR-T kunovimbisa mikana yakakura yekurapa kenza.