Te lymphoma pūtau-B nui horapa (DLBCL)-04

I kitea a Mr. Li, 64 tau te pakeke (ingoa huna), he mate pukupuku nui B-pūtau horapa (DLBCL) e whā tau ki muri, kua horapa ki te wāhanga whakamutunga o te whēkau, ngā rara, ngā pukahukahu, me te pleura, i whakarōpūtia ko te wāhanga IV. Whai muri i te immunochemotherapy raina tuatahi, i noho tonu tōna āhua ki te whakaoranga mō ngā tau neke atu i te toru. Heoi, i te marama o Poutū-te-rangi o te tau kua hipa, ka hoki anō tōna mate, ka uru atu ki ngā kōpū lymph retroperitoneal maha. Ahakoa te chemotherapy whakaora raina tuarua, he whakaoranga wāhanga noa iho tana i whiwhi, ā, ka tere te heke, me te hiahia kia nui ake te maimoatanga whai hua hei whakahaere i te whanaketanga atu.

I te aroaro o tēnei wero nui, i arotakehia whānuitia e te tīma tohunga i BIOOCUS Medical Group te take a Mr. Li, ā, i karangatia he hui tīma maha-mātauranga (MDT) hei taunaki i te rongoā pūtau CAR-T. Ko te rongoā pūtau CAR-T, te momo rongoā ārai mate hou o te pukupuku, he painga nui pērā i te arotahi kaha me te whai huatanga pumau mō ngā tūroro e pāngia ana e te lymphoma kua hoki mai me te uaua ki te mate.

I te marama o Hānuere 2023, i whiwhi a Mr. Li i te rongoā pūtau CAR-T i te Tari Lymphoma. I mua i te rongoā, i whiwhi ia i te koiora o ngā kōpū lymph inguinal matau, ā, i whakaū i te pai o te CD19 me te CD20, e whakarato ana i ngā whāinga mārama mō te rongoā pūtau CAR-T. I raro i te arataki a Ahorangi Li, i hangaia e te tīma hauora he mahere rongoā whaiaro.

I te 25 o Hūrae, 2023, i oti i a Mr. Li te werohanga o ngā pūtau CD19/20 CAR-T, ā, i haere pai tonu i raro i te aroturukitanga a te tīma hauora. Ahakoa te pāngia e te mate tukunga cytokine, te cytopenia, me ngā tūponotanga mate i muri i te werohanga, i angitu te whakahaere a te atawhai tautoko pakari i ngā urupare kino i te wā o te maimoatanga.

E ono marama i muri i te whakatinanatanga o te rongoā pūtau CAR-T, kāore a Mr. Li i whakaatu i ngā whara kaha nui puta noa i tōna tinana, ā, i tutuki ai te urupare pākia katoa (CMR), i puta ai he tumanako hou mō tōna hauora. I tāpirihia anō e te tīma hauora ngā whara retroperitoneal toenga ki te rongoā irahiko hei whakarite kia hoki katoa te mate me te pumau mō te wā roa.

Nā tēnei rongoā ārai mate pūtau CAR-T, kāore i te nui noa te whakapainga o te āhua o Mr. Li, engari i hoki mai anō hoki tōna whakapono me tōna hihiko ki te ao. He tumanako hou, he aronga hou hoki tāna mō ngā tūroro lymphoma, ā, e whakaatu ana i te kaha me te whai huatanga o te rongoā pūtau CAR-T ki te rongoā i te lymphoma uaua ki te rongoā.

Ko te rongoā pūtau CAR-T, hei rongoā mate pukupuku auaha, kei te whakarerekē i ngā ara o te oranga o ngā tūroro e pāngia ana e te lymphoma uaua. I raro i te manaakitanga a te tīma tohunga i te Tari Lymphoma, ka taea e ngā tūroro pērā i a Mr. Li te tumanako ki ngā whakapainga nui ki te oranga me te kounga o te oranga. I te tirohanga whakamua, ko ngā whanaketanga me ngā whakamahinga o te rongoā pūtau CAR-T e kī ana he whānui ake ngā tūmanako me ngā mea ka taea i roto i te rongoā mate pukupuku.