Lymphoma nini ya B-cell lymphoma (DLBCL)-04

Bwana Li, w'imyaka 64 (izina ry'ibanga), yasanzwemo indwara ya lymphoma ya B-cell lymphoma (DLBCL) mu myaka ine ishize, yari yarageze ku rwego rwo hejuru rw'agace k'umugongo, imbavu, ibihaha, na pleura, byashyizwe mu cyiciro cya kane. Nyuma yo guhabwa imiti igabanya ubukana bwa immunochimiotherapie ku rwego rwa mbere, indwara ye yakomeje kugabanuka mu gihe cy'imyaka irenga itatu. Ariko, muri Werurwe umwaka ushize, indwara ye yongeye kugaruka, iterwa n'udukoko twinshi twa lymph nodes. Nubwo yahabwaga imiti igabanya ubukana bwa chemotherapy ku rwego rwa kabiri, yakize igice gusa kandi yihuta cyane, biba ngombwa ko avurwa neza kugira ngo akomeze gutera imbere.

Ubwo bahuraga n'iki kibazo gikomeye, itsinda ry'impuguke muri BIOOCUS Medical Group ryasuzumye byimbitse ikibazo cya Bwana Li, rinatumiza inama y'itsinda ry'abahanga mu nzego zitandukanye (MDT) kugira ngo batange inama ku buvuzi bwa CAR-T cell therapy. Ubuvuzi bwa CAR-T cell therapy, nk'uburyo bugezweho bwo kuvura indwara z'ibibyimba, butanga ibyiza bikomeye nko kwibanda ku barwayi ba lymphoma yasubiye inyuma kandi idashobora kugaragara.

Muri Mutarama 2023, Bwana Li yavuwe na CAR-T cell therapy mu Ishami rya Lymphoma. Mbere yo kuvurwa, yakorewe biopsy y'uturemangingo tw'iburyo tw'inguinal, byemejwe ko CD19 na CD20 ari ingirakamaro, bitanga intego zisobanutse neza zo kuvura CAR-T cell. Bayobowe na Porofeseri Li, itsinda ry'abaganga ryateguye gahunda yihariye yo kuvura.

Ku ya 25 Nyakanga 2023, Bwana Li yarangije igikorwa cyo gutera uturemangingo twa CD19/20 CAR-T, cyakomeje neza gikurikiranwa neza n'itsinda ry'abaganga. Nubwo bahuye n'indwara yo gusohora uturemangingo twa cytokine, cytopenia, ndetse n'ingaruka zo kwandura nyuma yo guterwa uturemangingo, ubuvuzi buhamye bwabashije guhangana n'ingaruka mbi mu gihe cyo kuvurwa.

Amezi atandatu nyuma yo gukoresha ubuvuzi bwa CAR-T cell therapy, Bwana Li nta bisebe bikomeye yagaragaje mu mubiri we wose, bituma agira igisubizo cyuzuye cya metabolic response (CMR), byamuzaniye icyizere gishya ku buzima bwe. Itsinda ry’abaganga ryongeyeho uburyo bwo kuvura indwara zisigaye hamwe na radiotherapy kugira ngo indwara zikomeze kugabanuka burundu kandi zikomeze kumera neza igihe kirekire.

Binyuze muri ubu buvuzi bw’umubiri bwa CAR-T, Bwana Li ntiyageze ku iterambere rikomeye mu buzima bwe gusa, ahubwo yanagaruriye icyizere n’ubuzima bwiza. Urubanza rwe rutanga icyizere gishya n’icyerekezo ku barwayi ba lymphoma kandi rugaragaza ubushobozi n’akamaro k’ubuvuzi bwa CAR-T mu kuvura lymphoma idashobora kwangirika.

Ubuvuzi bwa CAR-T cell therapy, nk'uburyo bushya bwo kuvura kanseri, burimo guhindura imibereho y'abarwayi ba lymphoma idashobora kugaragara. Bitewe n'ubwitonzi bw'itsinda ry'inzobere mu ishami rishinzwe ubuvuzi bwa Lymphoma, abarwayi benshi nka Bwana Li bashobora kwitega iterambere rikomeye mu kubaho no mu mibereho myiza. Mu gihe urebye imbere, iterambere rikomeje no gukoresha ubuvuzi bwa CAR-T cell therapy bisezeranya amahirwe menshi n'amahirwe menshi mu kuvura kanseri.