Lymphoma nini ya B-cell lymphoma (DLBCL)-03 ikwirakwira mu mubiri

Muri Werurwe 2021, Bwana Wang (izina ry'ibanga) yumvise ububabare bw'inda yo hasi mu buryo butunguranye, abanza kwitiranya no kubabara mu nda, kandi ntiyahise ajya kwa muganga. Mu mezi abiri yakurikiyeho, yagiye ahura n'ibimenyetso by'ububabare bw'inda yo hasi mu buryo bukurikira, bituma ajya kwa muganga mu bitaro byo mu gace k'iwabo. Isuzuma rya CT ryagaragaje ko hari ibitagenda neza mu mara no kwiyongera kw'uturemangingo tw'amaraso mu mara.

Abaganga bamugiriye inama yo gupima indwara ya colonoscopy na biopsy kugira ngo bamenye byinshi ku ndwara, ibyo byemeza ko "lymphoma nini ya B-cell lymphoma ikwirakwira," ikibyimba kibi kizwi cyane nka lymphoma. PET-CT yemeje ko ibisebe bya nodular hypermetabolic byakwirakwiriye mu mubiri we wose, aho kinini cyanganaga na cm 4.3 * 4.1 * 4.5.

Ku nkunga y'umuryango we, Bwana Wang yakorewe imiti ya R-CHOP inshuro enye. Nyuma yo guhabwa imiti ya PET-CT nyuma yo guhabwa imiti ya chemotherapy, yagaragaje ko yagabanutseho igice cy'indwara.

Ariko, uburyo bwo kuvura bwakurikiyeho bwateje ibibazo bikomeye kuri Bwana Wang, nko kuziba amara, gutobora, no gucika kw'amaraso mu mara. Abaganga b'inzobere mu kubaga igifu n'abaganga bamuvura bafatanyije mu gikorwa cyo kubaga, bakamuca amara no kumukuraho amazi, hamwe no kumuvura ibimenyetso, bakamuvura neza ibimenyetso by'igifu.

Nyuma yo gusuzuma PET-CT, hagaragaye ko ibibyimba bya kanseri byiyongera kandi ko ingano yabyo yari iri hejuru. Kugira ngo bakureho neza uturemangingo twa kanseri, abaganga bahinduye uburyo bwo gukoresha imiti ya kanseri mu buryo buhanitse, banasaba ko hashyirwaho uturemangingo tw’amaraso dushyirwa mu maraso.

Mu gihe yahuraga n'ibibazo byinshi, Bwana Wang yahuye n'imibabaro ikomeye y'umubiri n'amarangamutima uko indwara ye yagendaga irushaho kuba mbi. Ibibyimba byagaragaye mu bice byinshi, aho ibisebe bishya bya multifocal nodular hypermetabolic byagutse cyane mu gace ka kanseri. Bitewe n'ibibyimba mu mubiri we wose, Bwana Wang yarwaye ububabare budakira bw'umubiri, bituma bigorana kuryama neza no gusinzira kubera ububabare.

Mu kwiheba, Bwana Wang yize ku buvuzi bwa CAR-T, uburyo bushya bwo kuvura ubudahangarwa bw’uturemangingo twa CAR-T bwagenewe abarwayi ba lymphoma ya B-cell yasubiye inyuma cyangwa idashobora kugaragara.

Mbere yo kuvurwa na CAR-T, isuzuma rya lymph node mu gace k'iburyo k'umugongo ryagaragaje ko CD19 na CD20 bifite ubushobozi bwo kuvura, ritanga intego nyazo zo kuvura uturemangingo twa CAR-T. Porofeseri Yu yateguye isuzuma ryimbitse ry’umubiri, bituma hashyirwaho gahunda yihariye yo kuvura CAR-T kuri Bwana Wang.

Ku ya 25 Nyakanga 2022, Bwana Wang yahawe selile za CD19/20 CAR-T mu bitaro, ubwo buryo bugenda neza. Gukurikiranira hafi no kwita ku buryo buhamye byagenzuye ingaruka mbi nyuma yo guterwa selile nta ngaruka zishobora gushyira ubuzima mu kaga.

Mu gihe kitarenze amezi atatu, ku ya 10 Ukwakira 2022, isuzuma rya PET-CT ryakurikiyeho ryemeje ko akize burundu, isuzuma rusange ryerekana ko ubuzima bwe bwazamutse cyane.

Mu gukurikirana nyuma, Bwana Wang yajyaga akorerwa isuzuma rya CT, MRI, cyangwa PET-CT, byose byemeza ko yakize burundu. Kugeza ubu, ubuzima bwe buracyari bwiza, burenga igihe cy’amezi arenga 14 cyo kumererwa neza.