Yaɗuwar babban ƙwayar cutar B-cell lymphoma (DLBCL)-04

An gano cewa Mr. Li, mai shekaru 64 (wanda ake kira da pseudonym), yana da cutar lymphoma mai girman B-cell (DLBCL) shekaru huɗu da suka gabata, wanda ya kai ga kamuwa da cutar spleen, haƙarƙari, huhu, da pleura a matakin ƙarshe, wanda aka rarraba a matsayin mataki na IV. Bayan maganin rigakafi na farko, yanayinsa ya ci gaba da raguwa tsawon shekaru sama da uku. Duk da haka, a watan Maris na bara, cutar ta sake dawowa, ta shafi ƙwayoyin lymph da yawa na retroperitoneal. Duk da maganin chemotherapy na biyu, ya sami sassauci kaɗan kawai kuma ya lalace cikin sauri, yana buƙatar magani mafi inganci don sarrafa ci gaba.

Da yake fuskantar wannan ƙalubale mai ban tsoro, ƙungiyar ƙwararru a BIOOCUS Medical Group ta yi nazari sosai kan lamarin Mr. Li kuma ta kira taron ƙungiyoyi daban-daban (MDT) don ba da shawarar maganin ƙwayoyin CAR-T. Maganin ƙwayoyin CAR-T, a matsayin sabon nau'in maganin rigakafi na ƙari, yana ba da fa'idodi masu mahimmanci kamar ingantaccen niyya da inganci mai ɗorewa ga marasa lafiya da ke fama da cutar lymphoma mai sake dawowa da rashin ƙarfi.

A watan Janairun 2023, an yi wa Mista Li maganin ƙwayoyin CAR-T a Sashen Lymphoma. Kafin a yi masa magani, an yi masa gwajin ƙwayoyin lymph na dama, wanda ya tabbatar da ingancin CD19 da CD20, wanda hakan ya samar da maƙasudai bayyanannu don maganin ƙwayoyin CAR-T. A ƙarƙashin jagorancin Farfesa Li, ƙungiyar likitoci ta tsara wani shiri na musamman na magani.

A ranar 25 ga Yuli, 2023, Mista Li ya kammala aikin jiko na ƙwayoyin CAR-T na CD19/20, wanda ya ci gaba cikin sauƙi ƙarƙashin kulawar da ƙungiyar likitoci ta yi masa. Duk da fuskantar matsalar sakin cytokine, cytopenia, da haɗarin kamuwa da cuta bayan jiko, kulawa mai ƙarfi ta taimaka wajen shawo kan mummunan sakamako yayin magani.

Watanni shida bayan aiwatar da maganin ƙwayoyin CAR-T, Mr. Li bai nuna wani mummunan rauni a jikinsa ba, wanda ya kai ga cikakken amsawar metabolism (CMR), wanda ya kawo sabon bege ga lafiyarsa. Ƙungiyar likitoci ta ƙara ƙara sauran raunukan da suka rage a baya da maganin radiotherapy don tabbatar da cikakken komawar cututtuka da kwanciyar hankali na dogon lokaci.

Ta hanyar wannan maganin rigakafi na ƙwayoyin CAR-T, Mr. Li ba wai kawai ya sami ci gaba mai mahimmanci a yanayinsa ba, har ma ya sake samun kwarin gwiwa da kuzari a rayuwa. Shari'arsa ta samar da sabon bege da alkibla ga marasa lafiya da cutar lymphoma kuma tana nuna yuwuwar da ingancin maganin ƙwayoyin CAR-T wajen magance cutar lymphoma mai rikitarwa.

Maganin ƙwayoyin CAR-T, a matsayin wani sabon maganin ciwon daji, yana canza yanayin rayuwar marasa lafiya da ke fama da cutar lymphoma mai saurin kamuwa da cuta. A ƙarƙashin kulawar kwararru a Sashen Lymphoma, ƙarin marasa lafiya kamar Mr. Li za su iya tsammanin samun ci gaba mai mahimmanci a rayuwa da ingancin rayuwa. Idan aka duba gaba, ƙarin ci gaba da amfani da maganin ƙwayoyin CAR-T yana ba da damar samun fa'idodi da dama a fannin maganin ciwon daji.