Gbasaa nnukwu lymphoma B-cell (DLBCL), NOS, ụdị GCB, isi sistemụ akwara etiti lymphoma-01

Na Disemba 2019, Maazị Wang, onye nkuzi si Northeast China, malitere inwe isi ọwụwa. Na Disemba 19, 2019, ule nchọpụta gosiri ihe ndị a: PET-CT gosipụtara onyinyo njupụta nke nwere mmụba dị ukwuu na metabolism FDG na mpaghara ikpere aka ekpe na corpus callosum (ihe dị ka 3.4 * 1.9 cm, SUVmax = 34.4). Biopsy na immunohistochemistry kwadoro nnukwu lymphoma B-cell diffuse (DLBCL, NOS, ụdị GCB), yana immunophenotype nke na-egosi Ki67(50%+), CD19(+), CD20(+), PAX5(+), CD79(+), MUM1(+), BCL(+), CD10(-/+), CD2(minor+). Nyocha mmiri cerebrospinal gosiri 6% mkpụrụ ndụ lymphoid na-etobeghị eto nwere mgbanwe morphological. Nchọpụta ahụ bụ isi akwara sistemụ akwara etiti (DLBCL, ụdị GCB).

Mgbe ọ nyochachara nhọrọ ọgwụgwọ dị n'ịntanetị, Maazị Wang mụtara maka ikike ọgwụgwọ BIOOCUS Medical Group ma chọọ ọkachamara ha ozugbo. Mgbe e mechara nyocha anụ ahụ zuru oke na nyocha nke ọma site n'aka ndị ọkachamara ụlọ ọgwụ ahụ, e kpebiri na Maazị Wang ga-esonye na nnwale ahụike maka ọgwụgwọ CART, karịsịa site na iji mkpụrụ ndụ CD19 CART. O natara ọgwụ CD19 CAR-T nke onwe ya na Eprel 24, 2023. Ka ọ na-erule Julaị 30, 2023, a chọpụtara na o nwetara mgbaghara zuru oke (CR) ma maliteghachila ndụ nkịtị.