Diffuse large B-cell lymphoma (DLBCL), NOS, GCB subtype, primary central nervous system lymphoma-01

Thaum Lub Kaum Ob Hlis 2019, Mr. Wang, ib tug xib fwb los ntawm Northeast China, tau pib mob taub hau. Thaum Lub Kaum Ob Hlis 19, 2019, kev kuaj mob tau qhia cov hauv qab no: PET-CT tau qhia txog qhov ntom ntom nrog kev nce ntxiv ntawm FDG metabolism hauv sab laug pem hauv ntej lobe thiab corpus callosum hauv caug cheeb tsam (kwv yees li 3.4 * 1.9 cm, SUVmax = 34.4). Biopsy thiab immunohistochemistry tau lees paub tias muaj diffuse loj B-cell lymphoma (DLBCL, NOS, GCB subtype), nrog rau immunophenotype qhia txog Ki67 (50% +), CD19 (+), CD20 (+), PAX5 (+), CD79 (+), MUM1 (+), BCL (+), CD10 (- / +), CD2 (me +). Kev tshuaj xyuas cov kua cerebrospinal tau qhia txog 6% ntawm cov hlwb lymphoid tsis paub tab nrog kev hloov pauv morphological. Kev kuaj mob yog thawj lub paj hlwb lymphoma (DLBCL, GCB subtype).

Tom qab tshawb nrhiav cov kev xaiv kho mob hauv online, Mr. Wang tau kawm txog BIOOCUS Medical Group lub peev xwm kho mob tiv thaiv kab mob thiab nrhiav lawv cov kev txawj ntse sai sai. Tom qab kev kuaj lub cev kom zoo thiab kev tshuaj xyuas zoo los ntawm pab pawg kws tshaj lij ntawm tsev kho mob, nws tau txiav txim siab tias Mr. Wang yuav koom nrog kev sim tshuaj CART, tshwj xeeb yog siv CD19 CART hlwb. Nws tau txais autologous CD19 CAR-T hlwb infusion rau lub Plaub Hlis 24, 2023. Thaum Lub Xya Hli 30, 2023, nws tau raug soj ntsuam tias tau ua tiav kev zam txim tag nrho (CR) thiab txij li ntawd los tau rov qab mus rau lub neej ib txwm.