Kufalitsa lymphoma yayikulu ya B-cell (DLBCL), NOS, mtundu wa GCB, dongosolo lalikulu la mitsempha yapakati lymphoma-01

Mu Disembala 2019, a Wang, mphunzitsi wochokera kumpoto chakum'mawa kwa China, anayamba kumva mutu. Pa Disembala 19, 2019, mayeso ozindikira matenda adavumbulutsa izi: PET-CT idawonetsa mthunzi wokhuthala wokhala ndi kagayidwe ka FDG kowonjezeka kwambiri kumanzere kwa lobe ndi bondo la corpus callosum (pafupifupi 3.4 * 1.9 cm, SUVmax = 34.4). Biopsy ndi immunohistochemistry zidatsimikizira diffuse large B-cell lymphoma (DLBCL, NOS, GCB subtype), yokhala ndi immunophenotype yomwe imasonyeza Ki67(50%+), CD19(+), CD20(+), PAX5(+), CD79(+), MUM1(+), BCL(+), CD10(-/+), CD2(minor+). Kusanthula kwa madzi a m'mitsempha ya ubongo kudavumbulutsa 6% ya maselo osakhwima a lymphoid omwe ali ndi kusiyana kwa mawonekedwe. Kuzindikira kumeneku kunali primary central nervous system lymphoma (DLBCL, GCB subtype).

Atafufuza njira zochiritsira pa intaneti, a Wang adaphunzira za luso la BIOOCUS Medical Group lochiza matenda a immunotherapy ndipo nthawi yomweyo adafunafuna ukatswiri wawo. Pambuyo pofufuza bwino thupi ndi kusanthula mosamala ndi gulu la akatswiri a chipatalacho, adaganiza kuti a Wang achite nawo mayeso azachipatala a CART therapy, makamaka pogwiritsa ntchito maselo a CD19 CART. Adalandira chithandizo cha CD19 CAR-T cell pa Epulo 24, 2023. Pofika pa Julayi 30, 2023, adapezeka kuti wapeza chikhululukiro chathunthu (CR) ndipo kuyambira pamenepo wabwerera ku moyo wabwinobwino.