Bambo D----Kuzindikira kwa ku Canada: Kufalitsa Lymphoma Yaikulu ya B-cell (DLBCL) yokhala ndi kusintha kwa TP53

Ife, monga chipatala, tinali ndi mwayi wothandiza wodwala dzina lake Bambo D, yemwe amachokera ku Canada. Anapezeka ndi matenda a Diffuse Large B-cell Lymphoma (DLBCL) omwe ali ndi kusintha kwa TP53, vuto lomwe linkabweretsa mavuto aakulu pa njira zochiritsira zachikhalidwe.

A D anayamba ulendo wawo wolimbana ndi matenda oopsawa ndi chiyembekezo komanso kulimba mtima komwe kunali kofanana ndi umunthu wawo. Poyamba, adapatsidwa mankhwala oyamba a R-CHOP chemotherapy, njira yodziwika bwino yothandizira DLBCL. Ngakhale kuti anali ndi chiyembekezo choyambirira, kuyesa kotsatira ndi mankhwala achiwiri monga R-DHAP ndi GEMOX-BTKi sikunaphule kanthu, zomwe zinapangitsa kuti vuto lake likhale losakhazikika, zomwe zinakhumudwitsa a D ndi gulu lawo lachipatala.

Pozindikira kufunika kwa vutoli komanso kufunika kwa njira zatsopano zothetsera mavuto, tinaganiza zophatikiza a D mu dongosolo la chithandizo cha CD19-CAR-T. Njira yatsopanoyi yochizira khansa imagwiritsa ntchito mphamvu ya chitetezo cha mthupi kuti chiwononge maselo a khansa, zomwe zikupereka chiyembekezo kwa odwala ngati a D omwe agwiritsa ntchito njira zochiritsira zachikhalidwe.

Zotsatira zake zinali zodabwitsa kwambiri. Mwezi umodzi wokha atangolandira maselo a CD19-CAR-T, a D adapeza mpumulo wathunthu, zomwe zinkaoneka ngati sizingatheke milungu ingapo yapitayo. Komabe, ulendowu wopita ku mpumulo sunali wopanda mavuto. A D adakumana ndi matenda a cytokine release syndrome (CRS) apakati komanso matenda a immunoeffector cell-associated neurotoxicity syndrome (ICANS) a grade 1 panthawi ya chithandizo. Mwamwayi, gulu lathu lachipatala losamala linalowererapo mwachangu, kuthana ndi mavutowa ndi tocilizumab, adalimumab, ndi mankhwala a mahomoni, ndikuwonetsetsa kuti a D ali otetezeka komanso omasuka panthawi yonseyi.

Kugwira ntchito bwino kwa chithandizo cha maselo a CAR-T pa mlandu wa a D kumapereka chiyembekezo kwa odwala a DLBCL omwe safuna chithandizo padziko lonse lapansi, kusonyeza kuthekera kosintha kwa njira yatsopano yochiritsira iyi. Kuphatikiza apo, ulendo wa a D ukugogomezera ntchito yofunika kwambiri yogwirira ntchito limodzi ndi chisamaliro chachifundo polimbana ndi khansa.

Poganizira zomwe adakumana nazo, a D adayamikira kwambiri thandizo losalekeza komanso luso la gulu lawo la zamankhwala. "Chisamaliro ndi kudzipereka komwe ndidalandira panthawi yonse ya chithandizo changa kunali kosayerekezeka," adatero. "Sikuti adangochiza matenda anga okha, komanso adasamalira zosowa zanga zamaganizo ndi zakudya, ndikuonetsetsa kuti ndikumva kuti ndikuthandizidwa pa sitepe iliyonse."

Nkhani ya a D ndi umboni wa kulimba mtima kwa mzimu wa munthu komanso kupita patsogolo kwakukulu komwe kukuchitika pankhani ya khansa. Pamene tikupitilizabe kupititsa patsogolo luso lazachipatala, tikupitirizabe kudzipereka kupereka chisamaliro chapadera komanso chachifundo kwa wodwala aliyense amene watipatsa thanzi ndi moyo wabwino.

Poyamba matendawa & tsiku limodzi lisanafike & mwezi umodzi mutalandira mankhwala.