VaD----Kuongororwa kweCanada: Kupararira kweB-cell Lymphoma (DLBCL) ine shanduko yeTP53

Isu, sechipatara, takava neropafadzo yekurapa murwere anonzi VaD, vanobva kuCanada. Vakaonekwa vaine chirwere cheDiffuse Large B-cell Lymphoma (DLBCL) chine TP53 mutation, chirwere chaive chakaoma zvikuru pakurapa kwechinyakare.

VaD vakatanga rwendo rwavo rwekurwisa chirwere ichi chinotyisa vaine tariro uye kutsunga kwakafanana nehunhu hwavo. Pakutanga, vakanyorerwa chemotherapy yemhando yekutanga yeR-CHOP, nzira yekurapa DLBCL. Pasinei netariro yekutanga, kuedza kwakatevera kurapwa kwemhando yechipiri senge R-DHAP neGEMOX-BTKi hakuna kubudirira, zvikaita kuti chirwere chavo chisashande, zvikaodza mwoyo VaD nechikwata chavo chekurapa.

Tichiziva kuti mamiriro ezvinhu ari kukurumidza uye kudiwa kwemhinduro itsva, takaita sarudzo yekubatanidza VaD muchirongwa chekurapa neCD19-CAR-T. Maitiro aya epamusoro ekurapa kenza anoshandisa simba remasoja emuviri kurwisa nekuparadza masero ekenza, zvichipa tariro kune varwere vakaita saVaD vakapedza nzira dzekurapa dzakajairika.

Mhedzisiro yacho yaishamisa zvikuru. Mwedzi mumwe chete mushure mekuiswa kwemasero eCD19-CAR-T, VaD vakawana relieve yakakwana, basa rairatidzika serisingagoneke mavhiki mashoma apfuura. Zvisinei, rwendo urwu rwerelieve rwakanga rusina matambudziko aro. VaD vakasangana ne intermediate-grade cytokine release syndrome (CRS) uye grade 1 immune effector cell-associated neurotoxicity syndrome (ICANS) panguva yekurapwa. Nerufaro, timu yedu yezvekurapa yakangwarira yakakurumidza kupindira, ichigadzirisa matambudziko aya ne tocilizumab, adalimumab, uye hormone therapy, zvichiita kuti VaD vagare vakachengeteka uye vanyaradzwe mukati menguva yese.

Kushanda zvakanaka kweCAR-T cell therapy munyaya yaVaD kunoshanda sechiratidzo chetariro kune varwere veDLBCL vasingadi kurapwa pasi rese, zvichiratidza kugona kwekuchinja kwenzira iyi yekurapa. Uyezve, rwendo rwaVaD runoratidza basa rinokosha rekushanda pamwe chete nemapoka akasiyana-siyana uye kutarisira netsitsi mukurwisa gomarara.

Vachifunga nezvezvakaitika kwavari, VaD vakatenda zvikuru rutsigiro rwakasimba nehunyanzvi hwechikwata chavo chekurapa. "Kutarisirwa kwandakaitwa uye kuzvipira kwandakawana mukurapwa kwangu kwakanga kusina muenzaniso," vakadaro. "Havana kungorapa chirwere changu chete, asi vakatarisirawo zvandinoda pamoyo uye pakudya, vachiona kuti ndainzwa ndichitsigirwa nhanho imwe neimwe."

Nyaya yaVaD inoratidza kuti mweya wemunhu wakasimba uye kufambira mberi kuri kuitwa munyaya dzekenza. Sezvatinoramba tichisimudzira miganhu yekuvandudza kurapa, tinoramba takazvipira kupa rubatsiro rwetsitsi kumurwere wese anotipa hutano hwavo nekugara zvakanaka.

Pakutanga kwechirwere uye zuva rimwe chete risati rasvika uye mwedzi mumwe mushure mekuisirwa mushonga.