Kupararira kweB-cell Lymphoma (DLBCL)

Murwere uyu, mukadzi akashinga ava kuda kusvika makore makumi masere ekuberekwa, akashinga kusangana nekuongororwa kwechirwere cheDiffuse Large B-cell Lymphoma (DLBCL), achiratidza ushingi hwakakura mukurwisa chirwere ichi chegomarara.

Kunyangwe akanga akura, akaramba akatsunga kukunda matambudziko akakonzerwa nechirwere chake. Zvisinei, mukati memwedzi mitanhatu mushure mekunge awana rubatsiro rwekutanga, akadzokera kuchirwere, zvichiratidza kuti chirwere chake chakanga chakanyanya kuipa. Pasinei nekuyedza kakawanda kurapwa kwechipiri nechechitatu, kenza yake yakaratidza kuramba yakasimba, zvichikonzera dambudziko guru kuchikwata chake chekurapa.

Vachiona kuti mamiriro ake ezvinhu ari kukurumidza, chikwata chevanachiremba chakatanga kutsvaga dzimwe nzira dzekurapa. Murwere uyu akanyoreswa muongororo yekiriniki inoongorora kurapwa kwemasero eCD19+22 CAR-T, nzira yemazuva ano inoshandisa masero eT akagadziriswa majini kurwisa masero egomarara ane maantigen chaiwo.

Mhedzisiro yacho yakanga inoshamisa zvikuru. Mwedzi mumwe chete mushure mekuiswa kwemasero eCD19+22 CAR-T, murwere akakwanisa kurerukirwa zvizere. Izvi hazvina kungomisa kufambira mberi kwechirwere chake chete asiwo zvakaita kuti masero ekenza apedzwe zvakanaka, zvichiratidza nguva inokosha murwendo rwake rwekurapwa.

Munguva yese yakaoma iyi, timu yezvekurapa yakapa rutsigiro rwakasimba uye kutarisira murwere. Kubva pakunyatso tarisa maitiro ake ekurapwa kusvika pakugadzirisa chero zviitiko zvakaipa, vakaita kuti hutano hwake hurambe huri chinhu chakakosha.

Achifunga nezvezvakaitika kwaari, murwere uyu akaratidza kutenda kukuru nekuda kwetsitsi dzaakapihwa. "Kuzvipira nehunyanzvi hwechikwata changu chekurapa zvaive zvinoshamisa zvechokwadi," akadaro. "Maitiro avo ekurapa akasarudzika akandipa tariro panguva yandaida zvakanyanya."

Kubudirira kwekurapwa kwemasero eCD19+22 CAR-T mukuwana kusunungurwa kwakakwana kunoratidza kugona kwayo senzira yekurapa ine tariro kune varwere veDLBCL vasingadi kurapwa. Nyaya iyi inoshanda seuchapupu hwesimba remishonga mitsva uye mishonga yakagadzirirwa munhu mukurapa kenza dzakaoma, kunyanya kuvarwere vakwegura vakaita semukadzi uyu ane ushingi.

Usati wasvika uye mwedzi mumwe mushure mekuisirwa mushonga