Kufalitsa Large B-cell Lymphoma (DLBCL)

Wodwalayo, mayi wolimba mtima yemwe ali pafupi ndi zaka 80, molimba mtima anapezeka ndi matenda a Diffuse Large B-cell Lymphoma (DLBCL), ndipo anasonyeza kulimba mtima kwakukulu polimbana ndi khansa yoopsayi.

Ngakhale kuti anali wokalamba, adatsimikiza mtima kuthana ndi mavuto omwe adakumana nawo chifukwa cha vuto lake. Komabe, patatha miyezi isanu ndi umodzi atachira ndi chithandizo choyamba, adabwereranso ku matenda ake, zomwe zidawonetsa kuti matendawa anali oopsa kwambiri. Ngakhale kuti adayesa kangapo chithandizo chachiwiri ndi chachitatu, khansa yake idawonetsa kukana kwake, zomwe zidapangitsa kuti gulu lake lachipatala livutike kwambiri.

Pozindikira kufunika kwa vuto lake, gulu lachipatala linayamba kufufuza njira zina zochiritsira. Wodwalayo analembetsa mu kafukufuku wachipatala wofufuza chithandizo cha maselo a CD19+22 CAR-T, njira yamakono yomwe imagwiritsa ntchito maselo a T opangidwa ndi majini kuti ayang'ane maselo a khansa omwe ali ndi ma antigen enaake.

Zotsatira zake zinali zodabwitsa kwambiri. Mwezi umodzi wokha atalandira maselo a CD19+22 CAR-T, wodwalayo anachira kwathunthu. Zotsatira zake zodabwitsa sizinangoyimitsa kupitirira kwa matenda ake komanso zinapangitsa kuti maselo a khansa athetsedwe bwino, zomwe zinali nthawi yofunika kwambiri paulendo wake wochiza.

Pa nthawi yonse yovutayi, gulu lachipatala linapereka chithandizo ndi chisamaliro chosasunthika kwa wodwalayo. Kuyambira kuyang'anitsitsa momwe amachitira chithandizo mpaka kuthana ndi zovuta zilizonse, adaonetsetsa kuti thanzi lake limakhalabe patsogolo.

Poganizira zomwe zinamuchitikira, wodwalayo anayamikira kwambiri chisamaliro chachifundo chomwe analandira. "Kudzipereka ndi luso la gulu langa lachipatala zinali zapadera kwambiri," adatero. "Njira yawo yochiritsira yokhayokha inandipatsa chiyembekezo panthawi yomwe ndinkachifuna kwambiri."

Zotsatira zabwino za chithandizo cha maselo a CD19+22 CAR-T pakukwaniritsa kuchira kwathunthu zikuwonetsa kuthekera kwake ngati njira yabwino yothandizira odwala a DLBCL osachira. Nkhaniyi ikutsimikizira mphamvu ya njira zatsopano zochiritsira komanso mankhwala apadera pochiza khansa yovuta, makamaka kwa odwala okalamba monga mayi wolimba mtima uyu.

Musanayambe & mwezi umodzi mutatha kulowetsedwa