- Unyango
- Ubungqina
- I-Neuroblastoma
- Ithumba Eliqinileyo
- Ubungqina
- Ii-TILS
- Unyango lweeSeli zeNK
- I-Myasthenia Gravis (MG)
- I-Acute Lymphoblastic Leukemia (B-ALL)
- I-Systemic Lupus Erythematosus (SLE)
- I-Acute Lymphoblastic Leukemia (T-ALL)
- I-NonHodgkin Lymphoma (NHL)
- I-Multiple Myeloma（MM）
- Ukusasaza i-B-cell Lymphom enkulu
- I-B-lymphocytic Leukemia
- I-Myeloma
I-Diffuse Large B-cell Lymphoma (DLBCL)
Isigulana, umfazi oqinileyo osondele kwiminyaka engama-80 ubudala, ngenkalipho wajongana nokufunyaniswa ukuba une-Diffuse Large B-cell Lymphoma (DLBCL), ebonisa inkalipho emangalisayo kumlo wakhe nxamnye nolu hlobo lomhlaza olunobundlongondlongo.
Nangona wayesele ekhulile, wahlala ezimisele ukoyisa imingeni eyayibangelwa yimeko yakhe. Nangona kunjalo, kwiinyanga ezintandathu emva kokufumana ukuphumla ngonyango lomgca wokuqala, waphinda wagula, nto leyo eyayibonisa ukuba isifo sakhe sasinzima. Nangona wayezama kaninzi unyango lomgca wesibini nowesithathu, umhlaza wakhe wabonisa ukumelana okungapheliyo, nto leyo eyayibangela umngeni omkhulu kwiqela lakhe lezonyango.
Beqonda ukuba imeko yakhe ingxamisekile, iqela lezonyango laqalisa umzamo wokuhlola ezinye iindlela zonyango. Esi sigulana sabhaliswa kuvavanyo lweklinikhi oluphanda unyango lweeseli ze-CD19+22 CAR-T, indlela entsha esebenzisa iiseli ze-T ezakhiwe ngokwezakhi zofuzo ukujolisa kwiiseli zomhlaza eziveza ii-antigens ezithile.
Iziphumo bezimangalisa ngokwenene. Kwinyanga nje emva kokufakwa kweeseli ze-CD19+22 CAR-T, isigulana safumana ukuphumla okupheleleyo. Esi siphumo simangalisayo asizange simise nje kuphela ukuqhubeka kwesifo sakhe kodwa sakhokelela ekuphelisweni ngempumelelo kweeseli zomhlaza, nto leyo eyayiphawula ixesha elibalulekileyo kuhambo lwakhe lonyango.
Kuyo yonke le nkqubo inzima, iqela lezonyango linike inkxaso engagungqiyo kunye nokhathalelo kwisigulana. Ukususela ekujongeni ngokusondeleyo indlela asabela ngayo kunyango ukuya ekulawuleni naziphi na iziganeko ezimbi, baqinisekisa ukuba impilo-ntle yakhe ihlala iyeyona nto iphambili.
Ecinga ngamava akhe, isigulana sibonakalise umbulelo omkhulu ngenkathalo yobubele esiyifumeneyo. "Ukuzinikela nobuchule beqela lam lezonyango bebubalasele ngokwenene," utshilo. "Indlela yabo yonyango eyenzelwe wena yandenza ndanethemba xa bendilifuna kakhulu."
Isiphumo esiphumeleleyo sonyango lweeseli ze-CD19+22 CAR-T ekufezekiseni ukuxolelwa ngokupheleleyo sigxininisa amandla alo njengokhetho lonyango oluthembisayo kwizigulane ze-DLBCL ezinganyangekiyo. Eli tyala lisebenza njengobungqina bamandla onyango olutsha kunye nonyango olulungiselelwe umntu ngamnye ekulawuleni umhlaza ontsonkothileyo, ngakumbi kwizigulane ezindala ezifana nalo mfazi unesibindi.
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