- Unyango
- Ubungqina
- I-Neuroblastoma
- Ithumba Eliqinileyo
- Ubungqina
- Ii-TILS
- Unyango lweeSeli zeNK
- I-Myasthenia Gravis (MG)
- I-Acute Lymphoblastic Leukemia (B-ALL)
- I-Systemic Lupus Erythematosus (SLE)
- I-Acute Lymphoblastic Leukemia (T-ALL)
- I-NonHodgkin Lymphoma (NHL)
- I-Multiple Myeloma（MM）
- Ukusasaza i-B-cell Lymphom enkulu
- I-B-lymphocytic Leukemia
- I-Myeloma
UMnu. D----Ukuchongwa kweKhanada: Ukusasaza i-Large B-cell Lymphoma (DLBCL) ene-TP53 mutation
Thina, njengesikhungo sezonyango, safumana ilungelo lokunyanga isigulana esibizwa ngokuba nguMnu. D, osuka eKhanada. Wafunyaniswa ukuba une-Diffuse Large B-cell Lymphoma (DLBCL) ene-TP53 mutation, imeko eyayibangela umngeni omkhulu kwiindlela zonyango zesintu.
UMnu. D waqalisa uhambo lwakhe lokulwa nesi sifo sinzima enethemba kunye nokuzimisela okufana nobuntu bakhe. Ekuqaleni, wafumana i-R-CHOP chemotherapy yodidi lokuqala, inkqubo yonyango eqhelekileyo ye-DLBCL. Nangona wayenethemba lokuqala, imizamo elandelayo yonyango lodidi lwesibini olufana ne-R-DHAP kunye ne-GEMOX-BTKi ayizange iphumelele, yashiya imeko yakhe ingasebenzi, nto leyo eyadanisa uMnu. D kunye neqela lakhe lezonyango.
Siqonda ukungxamiseka kwale meko kunye nesidingo sezisombululo ezintsha, senze isigqibo sokubandakanya uMnu. D kwisicwangciso sonyango lwe-CD19-CAR-T. Le ndlela iphambili yonyango lomhlaza isebenzisa amandla omzimba wokuzikhusela ekujoliseni nasekutshabalaliseni iiseli zomhlaza, nto leyo enika ithemba kwizigulana ezinjengoMnu. D eziye zasebenzisa iindlela zonyango eziqhelekileyo.
Iziphumo bezimangalisa kakhulu. Kwinyanga nje emva kokufakwa kweeseli ze-CD19-CAR-T, uMnu. D wafumana uxolelo olupheleleyo, into eyayibonakala ingenakwenzeka kwiiveki ezimbalwa ngaphambili. Nangona kunjalo, olu hambo lokuxolelwa belungekho ngaphandle kwemingeni yalo. UMnu. D wadibana ne-intermediate-grade cytokine release syndrome (CRS) kunye ne-grade 1 immune effector cell-associated neurotoxicity syndrome (ICANS) ngexesha lonyango. Ngethamsanqa, iqela lethu lezonyango elilumkileyo langenelela ngokukhawuleza, lilawula ngempumelelo ezi ngxaki nge-tocilizumab, i-adalimumab, kunye nonyango lwe-hormone, liqinisekisa ukhuseleko kunye nentuthuzelo kaMnu. D kuyo yonke inkqubo.
Ukusebenza kakuhle konyango lweeseli ze-CAR-T kwimeko kaMnu. D kusebenza njengesibane sethemba kwizigulane ze-DLBCL ezingaguqukiyo kwihlabathi liphela, kubonisa amandla okuguqula olu hlobo lonyango oluphambili. Ngaphezu koko, uhambo lukaMnu. D lugxininisa indima ebalulekileyo yokusebenza ngokubambisana kwamacandelo amaninzi kunye nokhathalelo olunobubele ekulweni nomhlaza.
Ecinga ngamava akhe, uMnu. D uvakalise umbulelo omkhulu ngenkxaso engagungqiyo kunye nobuchule beqela lakhe lezonyango. "Inqanaba lokhathalelo nokuzinikela endikufumeneyo kulo lonke unyango lwam belungenakuthelekiswa nanto," utshilo. "Abanyanganga isifo sam kuphela, kodwa bakwanyamekela neemfuno zam zeemvakalelo nezondlo, beqinisekisa ukuba ndiziva ndixhaswa kuyo yonke inyathelo."
Ibali likaMnu. D lingqina lokuqina komoya womntu kunye nenkqubela phambili emangalisayo eyenziwayo kwicandelo le-oncology. Njengoko siqhubeka nokuphucula iindlela zonyango, sizimisele ukubonelela ngononophelo olukhethekileyo nolunobubele kumntu ngamnye osiphathise impilo yakhe kunye nokuphila kakuhle.
Ekuqaleni kwesi sifo kunye nosuku olunye ngaphambi kunye nenyanga emva kokufakwa.
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