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Ho hasanya lymphoma e kholo ea B-cell (DLBCL), NOS, mofuta oa GCB, sistimi ea methapo ea mantlha ea mantlha lymphoma-01
Ka Tshitwe 2019, Monghadi Wang, tichere e tswang Leboya-botjhabela la China, o ile a qala ho opeloa ke hlooho. Ka la 19 Tshitwe 2019, diteko tsa tlhahlobo di senotse tse latelang: PET-CT e bontshitse moriti o teteaneng o nang le metabolism e eketsehileng haholo ya FDG karolong e ka letsohong le letshehadi ya lobe le ka pele le sebakeng sa lengole sa corpus callosum (hoo e ka bang 3.4 * 1.9 cm, SUVmax=34.4). Biopsy le immunohistochemistry di tiisitse diffuse large B-cell lymphoma (DLBCL, NOS, GCB subtype), ka immunophenotype e bontshang Ki67(50%+), CD19(+), CD20(+), PAX5(+), CD79(+), MUM1(+), BCL(+), CD10(-/+), CD2(minor+). Tlhahlobo ya mokelikeli wa boko e senotse 6% ya disele tsa lymphoid tse sa holang tse nang le phapang ya sebopeho. Tlhahlobo e ne e le lymphoma ya mantlha ya methapo ya kutlo (DLBCL, GCB subtype).
Kamora ho etsa lipatlisiso ka mekhoa ea kalafo inthaneteng, Monghali Wang o ile a ithuta ka bokhoni ba BIOOCUS Medical Group ba ho phekola mafu a 'mele' me a batla tsebo ea bona kapele. Kamora litlhahlobo tse tebileng tsa 'mele le tlhahlobo e hlokolosi ea sehlopha sa litsebi sa sepetlele, ho ile ha etsoa qeto ea hore Monghali Wang o tla nka karolo tekong ea bongaka bakeng sa phekolo ea CART, haholo-holo ho sebelisoa lisele tsa CD19 CART. O ile a fuoa infusion ea sele ea CD19 CAR-T ka la 24 Mmesa, 2023. Ka la 30 Phupu, 2023, o ile a hlahlojoa hore o fihletse phomolo e felletseng (CR) 'me ho tloha ka nako eo o khutletse bophelong bo tloaelehileng.
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