Myeloma nyinshi (MM) -02

Umurwayi w'Umutaliyani arashaka kuvurwa kandi arakira indwara ya Myeloma nyinshi akoresheje CAR-T therapy

Umukecuru witwa Cinty w'imyaka 66, yasanzwemo indwara ya lambda light chain multiple myeloma, ISS stage I, mu Butaliyani mu Ukwakira 2018. Nyuma yo guhabwa imiti ya VTD inshuro 4, yavunitse igice cya gatatu cy'umutwe wa clavicle na peripheral neuropathy. Ashaka ubuvuzi bwiza kurushaho, yatewe uturemangingo tw’umubiri inshuro ebyiri muri Gicurasi 2019 no mu Ugushyingo 2019, akira burundu, kandi agumana imiti ya lenalidomide yo mu kanwa.

Ariko, muri Kanama 2020, isuzuma rya PET/CT ryakurikiyeho ryagaragaje ko amagufwa yangiritse kandi ko imiyoboro y’urumuri idafite amaraso yiyongera cyane. Isuzuma ry’umusemburo w’amagufwa ryagaragaje ko indwara ikomeje kwiyongera, naho isuzuma rya FISH ryagaragaje ko hari ikibazo gishya cy’ubutabire: t (11; 14). Nyuma y’inshuro 4 zo gukoresha imiti ya DVD kuva muri Nzeri 2020, indwara ye ntiyagenzuwe kandi yakomeje kwiyongera. Nubwo yahinduye inshuro 3 zo gukoresha imiti ya PCd, ububabare bwe mu magufwa bwakomeje kandi kubyimba kw’amaguru yombi byo hasi byararushijeho kwiyongera. Amaze kugabanya uburyo bwinshi bwo kuvura buzwi ku rwego mpuzamahanga kandi akorerwa ubwoko bubiri bw’uturemangingo tw’umubiri, yagize ubudahangarwa ku miti myinshi.

Amaze kumenya akamaro gakomeye k'igeragezwa rya CAR-T mu kigo cyacu cya CGT binyuze mu makuru yo kuri interineti, yasabye viza maze agera mu Bushinwa muri Werurwe 2021. Nyuma y'ukwezi yamaze mu kato, yinjiye mu kigo cyacu cya CGT ku ya 22 Mata 2021. Nyuma y'ibizamini byinshi n'isuzuma ry'indwara, yahawe selile za BCMA CAR-T nyuma yo guhabwa imiti ya chimiotherapie ya FC muri Gicurasi uwo mwaka. Nyuma yo guhabwa imiti, ibimenyetso bye by'ubuzima byari bihagaze neza, kandi nta ngaruka mbi yagize uretse umuriro muke. Kubyimba kw'amaguru ye yo hasi byagabanutse buhoro buhoro, kandi yishimiye kubona ubuzima bwe muri rusange butera imbere.

Nyuma y'ukwezi kumwe ahawe CAR-T, ibisubizo bya Cinty byagaragaje ko: gupima poroteyine y'inkari mu masaha 24 kuri 50 mg / ku munsi, byagabanutse cyane ugereranyije n'urugero rw'imiti ikoreshwa; urunigi rw'urumuri rudafite amaraso: FLC-κ kuri 4.58 mg / L na FLC-λ kuri 0.61 mg / L; kandi isuzuma ry'umusemburo w'amagufwa nta tunyangingo tw'amaraso dufite. Yapimwe mu buvuzi ko ari mu kigero cyo kuruhuka burundu (CR).

Ubu, nyuma y'amezi umunani agarutse mu Butaliyani, ububabare bw'umugongo wa Cinty n'ibibyimba byo hasi ku maguru yombi byarashize burundu, kandi afite ubuzima bwiza. Aturutse mu birometero ibihumbi n'ibihumbi uvuye aho, Cinty yashimiye byimazeyo ikigo cyacu cya CGT.

Izi ndwara ebyiri zo kwa muganga zavuye muri BIOOCUS Medical Group zigaragaza ko n'abarwayi bafite BCMA nke cyangwa ntayo bafite muri myeloma nyinshi bashobora kugira ingaruka nziza bakoresheje uburyo bwa BCMA CAR-T. Ibi bigaragaza iterambere mu kuvura CAR-T myeloma nyinshi, bitanga icyizere gishya ku barwayi bafite ibibazo bikomeye by'uturemangingo tw'amaraso mu maraso na myeloma nyinshi.