Multiple Myeloma(MM)-02

Murwere wekuItaly ari kutsvaga kurapwa uye anorapwa chirwere cheMultiple Myeloma neCAR-T Therapy

Cinty, mukadzi ane makore makumi matanhatu nematanhatu ekuberekwa, akaonekwa aine chirwere che lambda light chain multiple myeloma, ISS stage I, muItaly muna Gumiguru 2018. Mushure mekupiwa chemotherapy yeVTD ka4, akatanga kutyoka muchikamu chechitatu che clavicle ne peripheral neuropathy. Achitsvaga kurapwa kunoshanda, akavhiyiwa kaviri muna Chivabvu 2019 naMbudzi 2019, achiwana relieve yakakwana, uye akachengetedzwa ne oral lenalidomide.

Zvisinei, muna Nyamavhuvhu 2020, PET/CT scan yakatevera yakaratidza kuparadzwa kwemapfupa matsva uye kuwedzera nekukurumidza kwemasero asina chiedza muropa. Kuongororwa kwemapfupa kwakaratidza kufambira mberi kwechirwere, uye kuongororwa kweFISH kwakaratidza kusagadzikana kutsva kwecytogenetic: t(11;14). Mushure memakore mana ekurapa chemotherapy kubva munaGunyana 2020, chirwere chake hachina kudzorwa uye chakaenderera mberi. Kunyangwe achichinja kuenda kumatanho matatu ePCd regimen, kurwadziwa kwemapfupa ake kwakaramba kuripo uye kuzvimba kwemakumbo epasi kwakawedzera. Mushure mekupedza kurapwa kwakawanda kunozivikanwa pasi rose uye akavhiyiwa kaviri autologous stem cell, akatanga kuramba mishonga yakawanda.

Paakanzwa nezvekushanda kwakakosha kwekuyedzwa kwekiriniki yeCAR-T panzvimbo yedu yeCGT kuburikidza neruzivo rwepaindaneti, akanyorera vhiza ndokusvika kuChina munaKurume 2021. Mushure memwedzi wekugara ari ega, akabvumidzwa kuCGT centre yedu musi waKubvumbi 22, 2021. Mushure mekuongororwa kwakawanda uye kuongororwa kwezvirwere, akapihwa BCMA CAR-T cells mushure mekurapwa neFC chemotherapy muna Chivabvu wegore rimwe chete. Mushure mekupihwa, zviratidzo zvake zvehupenyu zvakagadzikana, uye haana kusangana nemigumisiro yakakosha kunze kwefivha yakaderera. Kuzvimba kwemakumbo ake epasi kwakadzikira zvishoma nezvishoma, uye akafara kuona hutano hwake hwese huchivandudzika.

Mwedzi mumwe mushure mekupinzwa CAR-T, mhedzisiro yebvunzo yaCinty yakaratidza: kuyerwa kwemapuroteni emuweti kwemaawa makumi maviri nemana pa50 mg/zuva, zvakaderera zvakanyanya kubva pahuwandu hwekupinda; cheni dzechiedza dzisina serum: FLC-κ pa4.58 mg/L uye FLC-λ pa0.61 mg/L; uye kuongororwa kwebone marrow hakuna kuratidza masero eplasma akakosha. Akaongororwa mukiriniki semunhu ari mukuregerera kwakakwana (CR).

Parizvino, mwedzi misere mushure mekudzokera kuItaly, kurwadziwa kwemusana kweCinty uye kuzvimba kwemakumbo nemakumbo zvanyangarika zvachose, uye ari muhutano hwakanaka. Kubva kure nemakiromita zviuru, Cinty yakaratidza kutenda kwake kwechokwadi kuCGT centre yedu.

Nyaya mbiri idzi dzekurapa kubva kuBIOOCUS Medical Group dzinoratidza kuti kunyangwe varwere vane BCMA shoma kana kuti vasina kuonekwa mu multiple myeloma vanogona kushanda zvakanaka neBCMA CAR-T cell therapy. Izvi zvinoratidza kubudirira mukurapa CAR-T kwe multiple myeloma, zvichiunza tariro itsva kuvarwere vane matambudziko eplasma cell uye multiple myeloma.