Matenda a Myeloma Yambiri (MM) -02

Wodwala wa ku Italy akufuna chithandizo ndipo wachiritsidwa matenda a Multiple Myeloma pogwiritsa ntchito CAR-T therapy

Cinty, mayi wazaka 66, adapezeka ndi lambda light chain multiple myeloma, ISS stage I, ku Italy mu Okutobala 2018. Atalandira chithandizo cha VTD chemotherapy kangapo, adasweka mbali yachitatu ya clavicle ndi peripheral neuropathy. Pofuna chithandizo chogwira mtima, adachitidwa opaleshoni kawiri ya autologous stem cell mu Meyi 2019 ndi Novembala 2019, zomwe zidapangitsa kuti akhululukidwe kwathunthu, ndipo adathandizidwa ndi lenalidomide pakamwa.

Komabe, mu Ogasiti 2020, PET/CT scan yotsatira inavumbulutsa kuwonongeka kwa mafupa atsopano komanso kuwonjezeka kwachangu kwa unyolo wopanda kuwala m'magazi. Kufufuza kwa mafupa kunasonyeza kupita patsogolo kwa matenda, ndipo kuyezetsa kwa FISH kunawonetsa vuto latsopano la cytogenetic: t(11;14). Pambuyo pa ma DVD regimen chemotherapy anayi kuyambira mu Seputembala 2020, matenda ake sanalamuliridwe ndipo anapitirira. Ngakhale kuti anasintha kupita ku ma PCd 3, kupweteka kwa mafupa ake kunapitirira ndipo kutupa kwa miyendo ya m'munsi kunakula kwambiri. Atatopa ndi mankhwala ambiri odziwika padziko lonse lapansi komanso atapatsidwa maselo awiri oyambira autologous, anayamba kukana mankhwala ambiri.

Atamva za kufunika kwa mayeso azachipatala a CAR-T ku malo athu a CGT kudzera pa chidziwitso cha pa intaneti, adapempha visa ndipo adafika ku China mu Marichi 2021. Pambuyo pa mwezi umodzi wokhala yekhayekha, adaloledwa ku malo athu a CGT pa Epulo 22, 2021. Pambuyo poyesedwa ndi kuwunika matenda osiyanasiyana, adalandira ma cell a BCMA CAR-T atalandira chithandizo cha chemotherapy cha FC mu Meyi chaka chomwecho. Pambuyo popatsidwa ma chemotherapy, zizindikiro zake za moyo zinali zokhazikika, ndipo sanakumane ndi zotsatirapo zoyipa kupatula kutentha thupi kochepa. Kutupa kwa miyendo yake yapansi kunachepa pang'onopang'ono, ndipo adasangalala kuona thanzi lake lonse likuyenda bwino.

Mwezi umodzi pambuyo pa kulowetsedwa kwa CAR-T, zotsatira za mayeso a Cinty zinasonyeza: kuchuluka kwa mapuloteni a mkodzo kwa maola 24 pa 50 mg/tsiku, komwe kunachepetsedwa kwambiri kuchokera pamlingo wololedwa; unyolo wopanda kuwala m'magazi: FLC-κ pa 4.58 mg/L ndi FLC-λ pa 0.61 mg/L; ndipo kuwunika kwa mafupa sikunawonetse maselo ofunikira a m'magazi. Anayesedwa kuchipatala kuti ali mu chikhululukiro chokwanira (CR).

Pakadali pano, miyezi isanu ndi itatu atabwerera ku Italy, ululu wa msana wa Cinty ndi kutupa kwa miyendo yonse ya m'munsi kwatha kwathunthu, ndipo ali ndi thanzi labwino. Kuchokera kutali kwambiri, Cinty yayamikira kwambiri malo athu ochitira opaleshoni ya CGT.

Milandu iwiri yachipatala iyi yochokera ku BIOOCUS Medical Group ikuwonetsa kuti ngakhale odwala omwe ali ndi vuto lochepa la BCMA kapena osawonetsa BCMA mu multiple myeloma amatha kuchita bwino ndi chithandizo cha maselo a BCMA CAR-T. Izi zikuyimira kupita patsogolo kwa chithandizo cha CAR-T cha multiple myeloma, zomwe zikubweretsa chiyembekezo chatsopano kwa odwala omwe ali ndi matenda apamwamba a plasma cell ndi multiple myeloma.