Ntau yam mob qog nqaij hlav (MM)-01

Kev Rov Zoo Zoo ntawm Tus Neeg Mob Multiple Myeloma Hauv Tsev Neeg uas Muaj Kev Kho Mob CAR-T Txawm Tias Tsis Muaj Kev Qhia Tawm BCMA

Ib tug poj niam mob uas tau kuaj pom tias muaj theem IIIA IgD-λ hom multiple myeloma hauv xyoo 2018 tau txais kev kho mob thawj kab feem ntau yog bortezomib. Tom qab 3 lub voj voog, nws tau txais kev zam txim tag nrho (CR). Thaum Lub Kaum Hli 2018, nws tau txais kev hloov pauv ntawm cov hlwb hematopoietic autologous ua kev kho mob sib koom ua ke, ua raws li kev kho mob nrog lenalidomide. Thaum Lub Plaub Hlis 2020, tus kab mob rov qab los, thiab nws tau txais 7 lub voj voog ntawm kev kho mob kab thib ob, ua rau muaj txiaj ntsig tsis zoo. Txij Lub Kaum Ob Hlis 2020 txog Lub Plaub Hlis 2021, nws tau txais chemotherapy feem ntau nrog daratumumab, tab sis cov pob txha hauv lub cev tseem pom 21.763% malignant monoclonal plasma cells, nrog cov saw hlau tsis muaj teeb meem λ ntawm 1470 mg / L thiab cov saw hlau tsis muaj teeb meem λ ntawm 5330 mg / L. Txog lub sijhawm no, nws tau siv tag nrho cov kev kho mob tseem ceeb thiab cov kev kho mob tshiab muaj nyob hauv tsev, suav nrog kev hloov pauv ntawm cov hlwb autologous, nrog rau kev nkag mus rau hauv CAR-T kev sim tshuaj yog qhov kev xaiv zoo tshaj plaws.

Tom qab cov kws kho mob hauv zos xa nws mus, nws tau mus rau Tsev Kho Mob Ludaopei thaum lub Tsib Hlis 10, 2021, vam tias yuav tau koom nrog lawv qhov kev sim tshuaj BCMA CAR-T rau ntau yam mob myeloma (MM). Thaum nws nkag mus rau hauv tsev kho mob, nws lub cev tsis muaj zog nrog mob dav dav thiab kub taub hau rov qab los. Kev kuaj mob dav dav tau lees paub tias "ntau yam mob myeloma, λ hom saw hlau, ISS theem III, R-ISS theem III, mSMART pawg neeg muaj kev pheej hmoo siab."

Kev ntsuas PET-CT qhia tau tias muaj kev ua haujlwm ntawm cov metabolism ntau ntxiv hauv cov nqaij mos mos hauv cov pob txha ntawm cov pob txha femurs thiab tibias, qhia txog kev koom tes ntawm qog nqaij hlav. Kev kuaj mob pob txha qhia tau tias muaj 60.13% ntawm cov hlwb malignant monoclonal plasma uas tsis muaj kev qhia tawm ntawm BCMA.

peb lub chaw CGT tau qhia rau tus neeg mob thiab nws tsev neeg txog qhov ua tau zoo ntawm kev kho mob tam sim no rau BCMA-negative multiple myeloma, uas txawm hais tias muaj peev xwm ua tau zoo raws li qee cov ntaub ntawv sau tseg, tab sis tsis muaj cov ntaub ntawv tseeb. Tom qab xav txog zoo, tus neeg mob thiab nws tsev neeg tau xaiv los ua raws li txoj kev npaj kho mob.

Tom qab ua ntej kho nrog FC regimen, BCMA CAR-T hlwb tau muab tso rau hauv lub Rau Hli 1, 2021, ntawm Tsev Kho Mob Ludaopei. Tus neeg mob tau kub taub hau tom qab txhaj tshuaj, uas maj mam tswj tau nrog kev kho mob tiv thaiv kev kis kab mob thiab kev txhawb nqa cov tsos mob. Kaum plaub hnub tom qab txhaj tshuaj, kev kuaj mob pob txha tsis pom muaj cov hlwb monoclonal plasma malignant seem. Peb caug ib hnub tom qab txhaj tshuaj, kev kuaj mob pob txha tseem tsis pom. Serum immunofixation tsis pom, serum free light chain λ nyob hauv qhov ntau thiab tsawg, thiab serum M protein tsis pom, qhia tias tus kab mob ploj mus tag.

Tam sim no, ntau tshaj 8 lub hlis tom qab tau txais BCMA CAR-T cell infusion, tus neeg mob tseem nyob hauv qhov kev zam txim tag nrho nrog kev rov zoo thiab kev txaus siab rau qhov tshwm sim ntawm kev kho mob.