Umfana onesibindi waseRashiya ulwa ne-neuroblastoma

Kukho inkwenkwana enesibindi egama linguLev Kovalev. Uneminyaka esi-7 kuphela ubudala, kwaye uvela eRashiya. Kutheni simbiza ngokuba nesibindi? Nasi ibali lakhe elikhuthazayo.

ULev wafunyaniswa ene-neuroblastoma kwiminyaka emibini eyadlulayo, umhlaza onzima owawusele uqhubekile nangona unyango lokuqala lwalusele luqalile. Usapho lwakhe lwaphazamiseka kakhulu xa lwafumanisa ukuba kukho ukubandakanyeka kwe-bone morrow kunye nezinye iingxaki eziboniswe kwi-scan kunye ne-biopsies. Emva kokukhetha okuninzi kwizibhedlele zasekuhlaleni, kubandakanya i-chemotherapy kunye notyando, esi sifo saqhubeka siqhubeka, kunye neempawu zokusasazeka kwe-metastasis kunye nomsebenzi ophantsi we-bone morrow. Befuna impumelelo, abazali bakhe bafuna unyango oluphambili phesheya baza bafumana i-BIOOCUS, iziko eliphambili kwi-immunotherapy yeseli.

Kwi-BIOOCUS, uLev wafumana unyango olukhethekileyo ukususela ekuqaleni. Iqela lethu lezonyango lamazwe ngamazwe libonelele ngovavanyo lwasimahla olusekelwe kwiirekhodi zakhe zonyango, likhokela usapho kuyo yonke inyathelo ngovelwano nangobuchule. Siqonda amandla onyango olutsha, sanika unyango lweeseli ze-GD2 CAR-T emva kokulungiswa kwangaphambili nge-fludarabine kunye ne-cyclophosphamide. Inkqubo yayingenazingxaki, ngenxa yezibonelelo zethu zanamhlanje kunye nabasebenzi abazinikeleyo abaqinisekisa ukungonwabi okuncinci kwisigulana esiselula kangaka. Emva kokufakwa, iiseli ze-CAR-T zikaLev zanda ngempumelelo, zafikelela kumanqanaba amangalisayo ngosuku lwe-10 nangaphezulu, nto leyo ekhokelele ekuphuculeni okukhulu kwimeko yakhe. I-MRI elandelayo ibonise ubungakanani bethumba obunciphileyo kunye nokudumba, nto leyo ephawula utshintsho olukhulu kwidabi lakhe.

Into eyenza i-BIOOCUS yahluke kukuzinikela kwethu kwinkonzo esemgangathweni ophezulu kunye neemveliso eziphambili. Unyango lwethu lwe-CAR-T lujolise kwiimpawu ezithile ezifana ne-GD2, nto leyo enika ithemba apho unyango lwendabuko lungaphumeleli khona. Iqela leenkonzo zezigulane liphathe zonke izinto ezifunekayo, ukusuka kuncedo lwe-visa ukuya kwiindawo zokuhlala ezikhululekileyo, okwenza amava angabi naxinzelelo kwiintsapho zamazwe ngamazwe. Usapho lukaLev luyayincoma inkxaso yeelwimi ezininzi kunye nokhathalelo olusebenza imini nobusuku olubenze bazive besekhaya.