Umfana onesibindi waseRussia ulwa ne-neuroblastoma

Kukhona umfana omncane onesibindi ogama lakhe linguLev Kovalev. Uneminyaka engu-7 kuphela ubudala, futhi uvela eRussia. Kungani simbiza ngokuthi unesibindi? Nansi indaba yakhe ekhuthazayo.

ULev watholakala ene-neuroblastoma eminyakeni emibili edlule, umdlavuza onzima owawusuqhubeke naphezu kokwelashwa kokuqala. Umndeni wakhe wadabuka kakhulu lapho bezwa ngokubandakanyeka komnkantsha wamathambo kanye nezinye izinkinga eziboniswe kuma-scan kanye nama-biopsies. Ngemva kwezinketho ezinzima ezibhedlela zasendaweni, okuhlanganisa ukwelashwa ngamakhemikhali kanye nokuhlinzwa, lesi sifo saqhubeka nokuthuthuka, ngezimpawu zokusabalala kwamathambo kanye nomsebenzi ophansi womnkantsha wamathambo. Bephelelwe yithemba ngentuthuko, abazali bakhe bafuna ukwelashwa okuthuthukile phesheya futhi bathola i-BIOOCUS, isikhungo esihamba phambili ekwelashweni kwamasosha omzimba.

Kwa-BIOOCUS, uLev wathola ukunakekelwa komuntu siqu kusukela ekuqaleni. Ithimba lethu lezokwelapha lamazwe ngamazwe linikeze ukuhlolwa kwamahhala okusekelwe kumarekhodi akhe ezokwelapha, liqondisa umndeni kuzo zonke izinyathelo ngozwela nangobuchwepheshe. Siqaphela amandla okwelashwa okusha, sanikeza ukwelashwa kwamaseli e-GD2 CAR-T ngemuva kokwelashwa kusengaphambili nge-fludarabine kanye ne-cyclophosphamide. Inqubo yayilula, ngenxa yezikhungo zethu zesimanje kanye nabasebenzi abazinikele abaqinisekisa ukungakhululeki okuncane kwesiguli esisesincane kangaka. Ngemva kokufakwa, amaseli e-CAR-T kaLev anda ngempumelelo, afinyelela amazinga amangalisayo ngosuku lwe-10 nangaphezulu, okwaholela ekuthuthukisweni okukhulu esimweni sakhe. I-MRI yokulandelela ibonise usayizi wesimila onciphile kanye nokuvuvukala, okuphawula iphuzu lokuguquka empini yakhe.

Okwenza i-BIOOCUS ihluke ukuzibophezela kwethu ekuhlinzekeni ngezinsizakalo ezisezingeni eliphezulu kanye nemikhiqizo esezingeni eliphezulu. Ukwelashwa kwethu kwe-CAR-T kuhlose izimpawu ezithile ezifana ne-GD2, okunikeza ithemba lapho ukwelashwa kwendabuko kungaphumeleli khona. Ithimba lezinsizakalo zeziguli liphathe zonke izinto zokuthutha, kusukela ekusizeni nge-visa kuya ezindaweni zokuhlala ezikhululekile, okwenza okuhlangenwe nakho kungabi nokucindezeleka emindenini yamazwe ngamazwe. Umndeni kaLev uncoma ukwesekwa kwezilimi eziningi kanye nokunakekelwa kwansuku zonke okwabenza bazizwa besekhaya.