- Kev Kho Mob
- Cov Lus Pov Thawj
- Neuroblastoma
- Mob qog khov kho
- Cov Lus Pov Thawj
- TILS
- Kev Kho Mob NK Cell
- Myasthenia Gravis (MG)
- Kab mob qog ntshav Lymphoblastic loj heev (B-ALL)
- Kab mob Lupus Erythematosus (SLE)
- Kab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)
- Cov kab mob qog nqaij hlav tsis yog Hodgkin (NHL)
- Ntau yam mob myeloma (MM)
- Diffuse Large B-cell Lymphoma
- Kab mob B-lymphocytic Leukemia
- Mob qog nqaij hlav
Ib tug tub hluas siab tawv los ntawm Russia tawm tsam neuroblastoma
Muaj ib tug me nyuam tub uas siab tawv hu ua Lev Kovalev. Nws muaj 7 xyoo xwb, thiab nws los ntawm teb chaws Russia. Vim li cas peb thiaj hu nws ua siab tawv? Nov yog nws zaj dab neeg txhawb siab.
Lev tau kuaj pom tias muaj neuroblastoma ob xyoos dhau los, ib qho mob qog nqaij hlav uas nyuaj heev uas tau loj hlob txawm tias pib kho mob. Nws tsev neeg tau tu siab heev thaum lawv paub txog kev koom tes ntawm cov pob txha thiab lwm yam teeb meem uas pom hauv kev luam theej duab thiab kev kuaj mob. Tom qab siv zog ntau yam kev xaiv hauv tsev kho mob hauv zos, suav nrog kev kho mob chemotherapy thiab phais, tus kab mob txuas ntxiv mus, nrog rau cov cim ntawm metastasis thiab cov pob txha ua haujlwm tsawg. Xav tau kev tshawb pom tshiab, nws niam nws txiv nrhiav kev kho mob siab dua txawv teb chaws thiab tshawb pom BIOOCUS, lub chaw ua haujlwm tseem ceeb hauv kev kho mob cellular immunotherapy.
Ntawm BIOOCUS, Lev tau txais kev saib xyuas tus kheej txij thaum pib. Peb pab neeg kho mob thoob ntiaj teb tau muab kev ntsuam xyuas dawb raws li nws cov ntaub ntawv kho mob, coj tsev neeg hla txhua kauj ruam nrog kev khuv leej thiab kev txawj ntse. Paub txog lub peev xwm ntawm cov kev kho mob tshiab, peb tau muab GD2 CAR-T cell therapy tom qab preconditioning nrog fludarabine thiab cyclophosphamide. Cov txheej txheem tau seamless, ua tsaug rau peb cov chaw kho mob zoo tshaj plaws thiab cov neeg ua haujlwm pabcuam mob siab rau uas tau ua kom tsis muaj kev tsis xis nyob rau tus neeg mob hluas. Tom qab infusion, Lev cov CAR-T cell tau nthuav dav zoo, ncav cuag cov theem zoo kawg nkaus los ntawm hnub 10 thiab dhau mus, ua rau muaj kev txhim kho tseem ceeb hauv nws tus mob. Kev ua raws li MRI qhia tau tias qhov loj me ntawm qog thiab edema txo qis, cim qhov tig hauv nws qhov kev sib ntaus sib tua.
Qhov ua rau BIOOCUS sib txawv yog peb txoj kev cog lus rau kev pabcuam zoo thiab cov khoom lag luam tshiab. Peb txoj kev kho mob CAR-T tsom mus rau cov cim tshwj xeeb xws li GD2, muab kev cia siab uas cov kev kho mob ib txwm tsis ua haujlwm. Pab neeg pabcuam neeg mob tau ua txhua yam kev xa khoom, los ntawm kev pabcuam visa mus rau qhov chaw nyob zoo, ua rau qhov kev paub tsis muaj kev ntxhov siab rau cov tsev neeg thoob ntiaj teb. Tsev neeg Lev qhuas kev txhawb nqa ntau hom lus thiab kev saib xyuas 24 teev uas ua rau lawv xav tias nyob hauv tsev.
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