Intsha Ibuyisa Ithemba Ngemva Kokuxilongwa Kwe-AML M4a Uhambo Lokuqina Nokululama

Ngo-2014, umfana omncane ogama lakhe linguXiao Pi (alias) watholakala ene-acute myeloid leukemia (AML). Naphezu kokululama kokuqala ngemva kokwelashwa ngamakhemikhali kabili, izinkinga ezibangelwa ukutheleleka okukhulu zamshiya ekhathele ngokomzimba nangokomzwelo, okwamenza wayeka ukwelashwa kwakhe futhi wafuna ezinye izindlela zokwelapha.

Ngo-2016, isimo sikaXiao Pi saphinde sabuya, ngokuhlolwa okuqinisekisa i-AML-M4a nokwembula izinguquko zofuzo eziyinkimbinkimbi, okuhlanganisa i-DEK-CAN kanye ne-NRAS. Ngemva kwezikhathi eziningi zokwelashwa ngamakhemikhali okungasebenzi kahle, uXiao Pi wabhekana nokuphelelwa yithemba, ezibuza ukuthi kungenzeka yini ukuthi alulame.

NgoSepthemba 2018, uXiao Pi wafuna usizo eSibhedlela iLu Daopei, ethola ithemba kuDkt. Xiong Min kanye nethimba lakhe lokufakelwa. Ukuhlolwa okuphelele kwembule isibikezelo esiyinselele, okuhlanganisa nephesenti eliphezulu lamangqamuzana anobungozi kanye nokukhubazeka okuyinkimbinkimbi kwe-chromosome. Kodwa-ke, ithimba likaDkt. Xiong lakha uhlelo lokwelapha ngamakhemikhali oluqondene nomuntu siqu.

Imiphumela yaletha ushintsho olukhulu: ngemva kwemijikelezo emibili yokwelashwa ngamakhemikhali, amangqamuzana kaXiao Pi abulalayo ancipha kakhulu, kanti amazinga akhe amancane esifo esisele (MRD) athuthuka kakhulu. Ethola ukuzethemba kabusha, uXiao Pi walungiselela isinyathelo esilandelayo: ukufakelwa kweseli le-hematopoietic stem cell (HSCT) esebenzisa umfowabo njengomnikeli.

NgoNovemba 2018, uXiao Pi waphumelela ukufakelwa lesi sitho. Naphezu kwezinkinga ezincane ngesikhathi sokulungiswa kwangaphambi kokufakelwa kanye nesifo esithile se-graft-versus-host (GVHD) ngemuva kokufakelwa, inqubo yaba yimpumelelo. Ukululama kukaXiao Pi kwaqashwa ngokucophelela futhi kwaphathwa kahle, okwamvumela ukuba anqobe lezi zithiyo.

Manje, eminyakeni emihlanu ngemuva kokufakelwa, uXiao Pi uyachuma. Njengensizwa enempilo futhi eqinisekayo, uphishekela izifundo zakhe eyunivesithi ayikhethile, ekhombisa ukuqina nokuzimisela okwachaza uhambo lwakhe.

Umyalezo Wokubonga
Umndeni kaXiao Pi ubonge ngokusuka enhliziyweni uDkt. Xiong Min, uDkt. Wang Gen, uDkt. Cui Zhen, kanye nethimba lonke lezokwelapha, abanolwazi nobubele babo okwaguqula ukuphelelwa yithemba kwaba yithemba.

"Ngaphandle kwemizamo engakhathali yethimba leSibhedlela iLu Daopei, ukuzalwa kabusha kukaXiao Pi bekungeke kwenzeke. Sihlala sibonga."