Intuthuko Entsha Ekwelashweni Nokuxilongwa Kwesistimu Yezinzwa Eyinhloko Ye-Lymphoma (PCNSL)

I-Primary Central Nervous System Lymphoma (PCNSL) uhlobo olungavamile lwe- I-Non-Hodgkin Lymphoma lokho kwenzeka kuphela ebuchosheni, emgogodleni, emehlweni, nasezindaweni ezizungezile, lapho i-brain parenchyma iyindawo evame kakhulu. Naphezu kwentuthuko enkulu ekuxilongweni nasekulashweni, i-PCNSL isalokhu ingenye yezinhlobo ze-lymphoma eziyinselele kakhulu futhi ezingabikezelwa kahle, kanti amazinga okusinda asasele ngemuva kwezinye izinhlobo ze-lymphoma.

Ucwaningo lwakamuva oluvela eStanford University Medical School luveze obala imiphumela yakamuva yezifo, izindlela zokuxilonga, kanye nezindlela zokwelapha i-PCNSL. Ukubuyekezwa, okushicilelwe ku- Imibiko Yamanje Ye-Neurology kanye Ne-Neuroscience, kugcizelela isidingo esibalulekile sokuxilongwa kusenesikhathi, njengoba i-PCNSL ingaphazamisa ngokushesha ukusebenza kwezinzwa kanye nesimo sokusebenza (PS), okwenza kube nzima ukwelashwa ngesikhathi.

I-PCNSL ivame ukubonakala kakhulu ezigulini ezingaphezu kweminyaka engama-60, kanye nokwanda kwesifo kubantu abadala. Lesi sifo sivame ukuveza izimpawu ezifana nokudideka, ikhanda elibuhlungu, kanye nokukhubazeka kwemizwa okugxile, yize ukuquleka kungavamile. I-Magnetic Resonance Imaging (MRI) iseyindlela ejwayelekile yokuxilonga, kodwa izinselele zisekhona ekuhlukaniseni i-PCNSL kwezinye izimila zobuchopho kanye nezimo ngenxa yezici ezihambisanayo.

Lokhu kubuyekezwa kugcizelela nendima yamasu okuxilonga athuthukile, njengamamodeli okufunda okujulile ekuhlaziyweni kwe-MRI, ukuthuthukisa ukunemba kokuxilonga. Ngaphezu kwalokho, ukubaluleka kokuguqulwa kwezakhi zofuzo njenge-MYD88 L265P kuqokonyiswe njenge-biomarker engaba khona yokuxilonga nokuqapha ukuqhubeka kwesifo, okunikeza indlela entsha yokwelashwa okunembe kakhudlwana.

Ukuze kwelashwe, i-Methotrexate (HD-MTX) esezingeni eliphezulu isalokhu iyitshe lesisekelo, evame ukuhlanganiswa nokwelashwa ngemisebe yobuchopho bonke (WBRT). Kodwa-ke, ucwaningo luyaqhubeka nokuhlola ukusebenza kahle kokunciphisa imithamo yemisebe ukuze kuncishiswe ubuthi be-neurological ngenkathi kugcinwa ukusinda okungenakho ukuqhubeka (PFS). Izindlela ezintsha ku-chemotherapy kanye nokwelashwa okungaba khona okungeziwe njenge-Glucarpidase zibonisa ithemba ekunciphiseni ubuthi kanye nokuthuthukisa imiphumela.

I-PCNSL iyisifo esiyinkimbinkimbi nesinolaka, kodwa ucwaningo oluqhubekayo luvula izindlela ezintsha zokwelapha kanye nokuthuthukisa isibikezelo seziguli. Njengoba lokhu kuqhubeka, ithemba liwukuthi amazinga okusinda kanye nekhwalithi yokuphila kweziguli ze-PCNSL kuzothuthuka kakhulu.