UDkt. Lu Peihua Wethula Impumelelo Ekwelashweni Kwe-CAR-T Emhlanganweni Waminyaka Yonke Wama-29 we-APBMT
Kusukela mhla ziyi-10 kuya ku-13 kuMfumfu, 2024, uMhlangano Waminyaka Yonke wama-29 we-Asia-Pacific Blood and Marrow Transplantation (APBMT) ububanjelwe eSingapore General Hospital, ngaphansi kwesihloko esithi “Ukusebenzisa Uhlelo Lokuzivikela Emzimbeni.” Njengochwepheshe ohamba phambili waseShayina, uDkt. Lu Peihua wamenywa ukuba anikeze inkulumo eyinhloko, ebonisa impumelelo emangalisayo yethimba lakhe ekuhumusheni nasekusebenziseni ukwelashwa kwamaseli e-CAR-T, ikakhulukazi ekwelapheni umdlavuza wegazi.
Yasungulwa ngo-1990, i-APBMT ingenye yezingqungquthela ezibaluleke kakhulu ze-hematology kanye nokufakelwa komnkantsha esifundeni sase-Asia-Pacific. Ngamalungu avela emazweni angu-22, isebenza njengeplatifomu yokubambisana yokwabelana ngocwaningo olusezingeni eliphezulu kanye nentuthuko yezokwelapha ekufakweni kwamaseli e-hematopoietic kanye nokwelashwa kwamaseli.
Enkulumweni yakhe enesihloko esithi "Idatha Yangempela Yezokwelapha Ze-CAR-T Ezemfundo eShayina," uDkt. Lu ugcizelele imiphumela yezokwelapha ephumelelayo efinyelelwe ngokwelashwa kwe-CD7 CAR-T kweziguli ezinomdlavuza wegazi ophinde wabuyela emuva noma ongaphili kahle. Iziguli eziningi, ezazinezinketho ezimbalwa ezisele, zithole ukuphulukiswa okuphelele ngokwelashwa kwe-CAR-T, kanti kwabanye, ezinye izindlela zokwelapha ezihlanganisiwe ezifana nokufakelwa umnkantsha wamathambo zanikeza ukuphulukiswa kwesikhathi eside ngisho nethuba lokwelashwa.
Isethulo sikaDkt. Lu sidonse amehlo kakhulu, ochwepheshe abaningana bezwakalisa intshisekelo enkulu yokubambisana. Ngemva kwesethulo, odokotela baseSingapore General Hospital bashintshana ngolwazi lokuxhumana noDkt. Lu, behlola ubudlelwano besikhathi esizayo. Bahlabeke umxhwele kakhulu ngemiphumela yokwelashwa ethembisayo etholwe yithimba lakhe futhi bazwakalisa intshisekelo yokudlulisela iziguli eShayina ukuze zithole ukwelashwa okuthuthukisiwe kwe-CAR-T.
Njengenye yezikhungo ezihamba phambili esifundeni sase-Asia-Pacific, iSingapore General Hospital inikeza isisekelo esiqinile sokubambisana kwesikhathi esizayo kokubili ocwaningweni kanye nasemisebenzini yezokwelapha. UDkt. Lu ugcizelele ukubaluleka kokubambisana okunjalo ekuthuthukiseni i-hematology kanye nokufakelwa komnkantsha ukuze kuzuze iziguli emhlabeni jikelele.
UDkt. Lu Peihua, onolwazi lwakhe olukhulu ekwelashweni kwe-CAR-T, ubelokhu ekhuluma njalo emihlanganweni yamazwe ngamazwe efana ne-APBMT. Isethulo sakhe sakamuva siphinde sagcizelela amandla okwelashwa kwe-CAR-T okuthuthukisa imiphumela yeziguli, ukugqugquzela ucwaningo olwengeziwe, nokukhuthaza ukubambisana komhlaba wonke. Ithimba lakhe lisazinikele ekuhlinzekeni ukwelashwa okusha nokwenziwe ngokwezifiso, ukuqinisekisa ukuthi iziguli ziyazuza ekuthuthukisweni kwakamuva kwesayensi yezokwelapha.
Ngokuqhubeka nokubambisana komhlaba wonke kanye nokwabelana ngolwazi, ithimba likaDkt. Lu lihlose ukuthuthukisa izinketho zokwelapha iziguli ezihlushwa umdlavuza wegazi nezinye izifo zegazi, lilwela ikusasa lapho izindlela zokwelapha ezintsha zinganikeza khona izixazululo ezihlala isikhathi eside.