UDkt. Lu Peihua Uveza Impumelelo kwi-CAR-T Therapy kwiNtlanganiso yoNyaka yama-29 ye-APBMT
Ukususela nge-10 ukuya kwi-13 ka-Okthobha, ngo-2024, iNtlanganiso yoNyaka yama-29 ye-Asia-Pacific Blood and Marrow Transplantation (APBMT) ibibanjelwe kwiSibhedlele iSingapore General, phantsi komxholo othi “Ukusebenzisa iNkqubo yoMzimba.” Njengengcali ephambili evela eTshayina, uGqr. Lu Peihua wamenywa ukuba enze intetho ephambili, ebonisa impumelelo ephawulekayo yeqela lakhe ekuguquleleni nasekusebenziseni unyango lweeseli zeCAR-T, ingakumbi kunyango lwe-blood mold.
Yasekwa ngo-1990, i-APBMT yenye yezona ngqungquthela zibalulekileyo ze-hematology kunye nokufakelwa komongo wethambo kummandla we-Asia-Pacific. Ngamalungu avela kumazwe angama-22, isebenza njengeqonga lokusebenzisana lokwabelana ngophando oluphambili kunye nophuhliso lweklinikhi ekufakweni kweeseli ze-hematopoietic stem kunye nonyango lweeseli.
Kwintetho yakhe enesihloko esithi "Idatha yokwenyani yezonyango ze-CAR-T eTshayina," uGqr. Lu ugxininise iziphumo zeklinikhi eziphumeleleyo ezifunyenwe ngonyango lwe-CD7 CAR-T kwizigulana ezine-relapse okanye umhlaza wegazi onganyangekiyo. Izigulana ezininzi, ezazineendlela ezimbalwa ezisele, zifumene uxolelo olupheleleyo ngonyango lwe-CAR-T, kwaye kwezinye, ezinye iindlela zonyango ezidibeneyo ezifana nokufakelwa komongo wethambo zibonelela ngoxolelo oluhlala ixesha elide kwanokuba nethuba lokunyanga.
Intetho kaGqr. Lu ifumene ingqalelo enkulu, iingcali ezininzi zibonakalise umdla omkhulu wokusebenzisana. Emva kwentetho, oogqirha baseSingapore General Hospital batshintshiselana ngolwazi loqhagamshelwano noGqr. Lu, behlola ubudlelwane bexesha elizayo. Bachukumiseke kakhulu ziziphumo zonyango ezithembisayo ezifunyenwe liqela lakhe kwaye babonakalise umdla wokuthumela izigulane eTshayina ukuze zifumane unyango oluphambili lwe-CAR-T.
Njengenye yeziko eziphambili kummandla weAsia-Pacific, iSingapore General Hospital inika isiseko esomeleleyo sokusebenzisana kwixesha elizayo kuphando nakwimisebenzi yeklinikhi. UGqr. Lu ugxininise ukubaluleka kobudlelwane obunjalo ekuphuculeni i-hematology kunye nokufakelwa komongo wamathambo ukuze kuzuze izigulane kwihlabathi liphela.
UGqr. Lu Peihua, onamava akhe amaninzi kunyango lwe-CAR-T, ubesoloko ethetha kwiingqungquthela zamazwe ngamazwe ezifana ne-APBMT. Intetho yakhe yakutshanje iphinde yagxininisa amandla onyango lwe-CAR-T okuphucula iziphumo zesigulana, ukukhuthaza uphando olongezelelekileyo, kunye nokukhuthaza intsebenziswano yehlabathi. Iqela lakhe lisazimisele ekuboneleleni ngonyango olutsha nolwenzelwe umntu ngamnye, ukuqinisekisa ukuba izigulana ziyazuza kuphuhliso lwamva nje kwisayensi yezonyango.
Ngokuqhubeka nentsebenziswano yehlabathi kunye nokwabelana ngolwazi, iqela likaGqr. Lu lijolise ekuphuculeni iindlela zonyango kwizigulane ezinesifo somhlaza wegazi kunye nezinye iingxaki zegazi, lizama ikamva apho unyango olutsha lunokubonelela ngezisombululo ezihlala ixesha elide.