Kupona Mumatambudziko: Rwendo rwemakore gumi nemana rwekutsungirira mukurwisa Stage IV Melanoma
Muna 2010, ava nemakore 48, Jennifer Ficko akaonekwa aine chirwere che melanoma chedanho rechina. Chakatanga sebundu mumusoro make chairatidzika sechisina njodzi chakazopedzisira chakonzera kushamisika kweThanksgiving apo vanachiremba vakasimbisa kutya kwake kukuru. Nyika yaJennifer, neyemhuri yake, yakachinja husiku pavakatarisana nechokwadi chakaoma chekenza yekupedzisira. Nekusakwanisa kusarudza kwakawanda, Jennifer nevadikanwi vake vakatsvaga rubatsiro uye pakupedzisira vakabatana nenyanzvi dzepamusoro paSmilow Cancer Hospital kuYale.
Pakutanga, Jennifer akavhiyiwa kubvisa bundu uye ma lymph nodes akanga akanganiswa. Akapindawo mukuyedzwa kwekiriniki kwekutsvaga mishonga inodzivirira immune checkpoint yakaita seYervoy (ipilimumab) uye gare gare mushonga wakabatana neNivolumab. Kunyange zvazvo akawana mhinduro, Jennifer akasangana nemigumisiro yakaipa, kusanganisira retina uye kurasikirwa nekunzwa, asi akaramba achirwisa.
Chinhu chakachinja muna 2017 apo chiremba wake wekenza, Dr. Harriet Kluger, akamukurudzira kuti aedze mushonga mutsva paYale Cancer Center, wakatarisana nekurapa kweTumor-Infiltrating Lymphocyte (TIL). Nenzira iyi yemazuva ano, vaongorori vakabvisa nekuwedzera maT-cell ake, ayo akazodzoserwa mumuviri wake kuti awedzere simba rekudzivirira chirwere chake kubva kugomarara. Kurapwa kwacho kwakanyanya kwakaita kuti aite zvinhu zvine simba asi pakupedzisira akatanga kuderedza mabundu ake.
Kupora kwaJennifer kwaive kwenguva refu uye kwakaoma. Simba rake nekusimba kwake, pamwe chete nekutsigirwa kwaakaitwa nemhuri yake nguva dzose, zvakamubatsira kukunda nguva iyi yakaoma. Nhasi uno, Jennifer haana chirwere chekenza uye ave aripo kwemakore anopfuura manomwe. Pazera remakore makumi matanhatu nerimwe, anofungisisa nezverwendo rwake nekutenda nechinangwa, achisimbisa kuti kuva nepfungwa dzakanaka nekusimba kwakakosha mukurwisa kenza. Vana vake, vachikurudzirwa nerwendo rwaamai vavo, ikozvino vari kutsvaga mabasa ekurapa.
Nyaya yaJennifer inoratidza kugona kweTIL therapy kuchinja, iyo yakagamuchirwa nekukurumidza neFDA, uye inopa tariro kuvarwere vakawanda vari kutarisana nematambudziko akafanana. Kushinga kwake uye kutsunga kwake kurarama zvizere zvinoshanda sechiedza chetariro, zvichiratidza kuti nerutsigiro rwemhuri, kufambira mberi mu Kurapa Kenza, uye maonero akanaka, zvishamiso zvinogona kuitika.