Ku saabsan shirkaddayadaDulmar Guud oo ku saabsan Daaweynta CAR-T

Daaweynta CAR-T, oo loo soo gaabiyo Chimeric Antigen Receptor T-Cell Immunotherapy, waa hab daaweyn hidde-side oo horumarsan oo ku lug leh wax ka beddelka hidde-sideyaasha unugyada T ee bukaanka si loo bartilmaameedsado loona burburiyo unugyada kansarka. Si ka duwan daawooyinka dhaqameed, daaweynta CAR-T waxaa loogu talagalay bukaan kasta waxayna u baahan tahay in unugyada T laga soo ururiyo dhiigga bukaanka ka hor inta aan dib loogu shubin jirka ka dib injineernimada hidde-sidaha.

Sahaminta Astaamaha

Tilmaamaha CAR-T

● Leukemia-da lymphoblastic ee ba'an ee unugyada B-cell

● Myeloma badan

● Leukemia-da lymphocytic ee daba-dheeraatay

● Lymphoma-ka aan ahayn Hodgkin

● Kala-goysyada waaweyn ee unugyada B-cell oo faafa

● SLE (Lupus Erythematosus oo nidaamsan)

Waxqabad caafimaad oo heer sare ah oo CAR-T ah

Tilmaamaha CD19+20CAR-T: Bukaannada qaba lymphoma-ka aan ahayn Hodgkin ee unugyada B

Heerka CR ee hal bil ah	Heerka PR ee hal bil	Hal bil AMA qiime	CRS≥3	CRES≥3
71.95%(59/82)	25.6（21/82）	97.55(80/82)	12.19%(10/82)	0

Tilmaamaha CD19+22CAR-T: Daaweynta bukaanada qaba cudurka 'B-lymphocytic leukemia' ee CD19 oo dib u soo noq noqday iyo kuwa aan firfircoonayn

Heerka CR ee hal bil ah	Heerka PR ee hal bil	Hal bil AMA qiime	CRS≥3	CRES≥3
92.1%(35/38)	7.9%(3/38)	100% (38/38)	15.79%(6/38)	0

Tilmaamaha loogu talagalay BCMACAR-T: Daaweynta myeloma badan oo soo noqnoqota iyo mid aan firfircoonayn

Heerka CR ee hal bil ah	Heerka PR ee hal bil	Hal bil AMA qiime	CRS≥3	CRES≥3
72.41%(21/29)	27.59%(8/29)	100% (29/29)	6.9%(2/29)	0

Maxaad Noo Dooranaysaa?

Faa'iidooyinkayaga

●Daaweynta Shakhsi ahaaneed: Waxaan u habeyneynaa daaweynta CAR-T bukaan kasta, annagoo hubinayna daaweyn bartilmaameedsan oo wax ku ool ah.

●Xulashooyinka Bartilmaameedka Kala Duwan: Badeecadahayaga CAR-T waxay bixiyaan xulashooyin badan oo bartilmaameed ah, oo ay ku jiraan CD7, CD19, CD20, CD22, iyo BCMA, iyagoo bixinaya faa'iidada ikhtiyaarrada daaweynta ee shakhsi ahaaneed ee bukaanada.

●Tiknoolajiyadda Casriga ah: Daawayntayada CAR-T waxay isticmaashaa horumarkii ugu dambeeyay ee injineernimada hidde-sidaha iyo daaweynta difaaca jirka.

●Waxtarka kharash-oolnimada sare: Marka la barbardhigo alaabada kale, waxaan bixinaa isku dheelitirnaan heer sare ah oo u dhaxaysa hubinta tayada iyo qiimaha tartanka.

●Khibrad Caafimaad: Iyadoo ay taageerayaan koox dhakhaatiir khibrad leh iyo cilmi-baarayaal ah, waxaanu bixinaa daryeel iyo taageero tayo sare leh inta lagu jiro habka daaweynta.

●Hab Dhammaystiran: Waxaan bixinaa daryeel dhammaystiran, laga bilaabo qiimaynta bukaanka ilaa maamulka daaweynta iyo dabagalka, iyadoo la hubinayo natiijooyinka ugu wanaagsan.