Ku bijyanye n'ikigo cyacuIncamake y'Ubuvuzi bwa CAR-T

Ubuvuzi bwa CAR-T, mu magambo ahinnye asobanura Chimeric Antigen Receptor T-Cell Immunotherapy, ni uburyo bugezweho bwo kuvura imiterere y’uturemangingo bukoresha uburyo bwo guhindura uturemangingo twa T tw’umurwayi kugira ngo twibasire kandi tumene uturemangingo twa kanseri. Bitandukanye n’imiti gakondo, ubuvuzi bwa CAR-T bugenewe buri murwayi kandi busaba gukusanya uturemangingo twa T mu maraso y’umurwayi mbere yo kongera kutwongerera mu mubiri nyuma yo gukora inyigo y’imiterere y’uturemangingo.

Suzuma Ibiranga

Ibimenyetso bya CAR-T

● Leukemia y'urumogi ifata selile B

● Mieloma nyinshi

● Leukemia idakira y’imitsi

● Lymphoma itari iya Hodgkin

● Lymphoma nini ya B-cell ikwirakwira

● SLE (Systemic Lupus Erythematosus)

Imikorere myiza cyane mu buvuzi bwa CAR-T

Ibimenyetso bya CD19+20CAR-T: Abarwayi bafite lymphoma ya B-cell non Hodgkin

Igipimo cya CR cy'ukwezi kumwe	Igipimo cy'ukwezi kumwe cya PR	Igipimo cya OR cy'ukwezi kumwe	CRS≥3	CRES≥3
71.95% (59/82)	25.6 (21/82)	97.55 (80/82)	12.19% (10/82)	0

Ibimenyetso bya CD19+22CAR-T: Kuvura abarwayi ba kanseri y'amaraso ya B-lymphocytic basubiye inyuma kandi badafite CD19

Igipimo cya CR cy'ukwezi kumwe	Igipimo cy'ukwezi kumwe cya PR	Igipimo cya OR cy'ukwezi kumwe	CRS≥3	CRES≥3
92.1% (35/38)	7.9% (3/38)	100% (38/38)	15.79% (6/38)	0

Ibimenyetso bya BCMACAR-T: Kuvura myeloma nyinshi yasubiwemo kandi idashobora kuvura

Igipimo cya CR cy'ukwezi kumwe	Igipimo cy'ukwezi kumwe cya PR	Igipimo cya OR cy'ukwezi kumwe	CRS≥3	CRES≥3
72.41% (21/29)	27.59% (8/29)	100% (29/29)	6.9% (2/29)	0

Kuki twahitamo?

Ibyiza byacu

●Ubuvuzi Bwite: Duhindura uburyo bwo kuvura CAR-T kuri buri murwayi, kugira ngo tubone uburyo bwo kuvura bunoze kandi bugamije ubuvuzi.

●Uburyo butandukanye bwo kuvura: Ibicuruzwa byacu bya CAR-T bitanga uburyo butandukanye bwo kuvura, harimo CD7, CD19, CD20, CD22, na BCMA, bitanga akarusho ko kuvura abarwayi ku giti cyabo.

●Ikoranabuhanga rigezweho: Ubuvuzi bwacu bwa CAR-T bukoresha iterambere rigezweho mu buhanga mu by’uturemangingo no kuvura indwara z’umubiri.

●Kugura neza: Ugereranyije n'ibindi bicuruzwa, dutanga uburinganire bwiza hagati yo kwemeza ubuziranenge n'ibiciro bishimishije.

●Ubuhanga mu by'ubuvuzi: Dushyigikiwe n'itsinda ry'abaganga n'abashakashatsi b'inararibonye, dutanga ubuvuzi bwiza n'ubufasha mu gihe cyose cyo kuvurwa.

●Uburyo bwuzuye: Dutanga ubuvuzi bwuzuye, kuva ku gusuzuma umurwayi kugeza ku gutanga ubuvuzi no gukurikirana, kugira ngo tubone ibisubizo byiza.