Inqanaba lomhlaza we-endometrial IVB-04

Isigulana yayingumfazi oneminyaka engama-55 ubudala, kwaye i-histopathology ye-biopsy iqinisekisile ukufunyaniswa kwesigaba se-IVB somhlaza we-endometrial esingachazwanga kakuhle.

Umahluko ophantsi kunye nomhlaza ophezulu. Ithumba lakhe lalisele ligugile kwaye alikwazanga ukususwa ngokupheleleyo ngotyando. Uvavanyo olongezelelweyo lubonise ukuba izigulane zazinciphile umlinganiselo kunye nokubalwa kwee-lymphocyte kunye nomsebenzi weeseli ze-NK ophantsi kakhulu. Engenakukwazi ukunyamezela iziphumo ezibi, wayeka i-chemotherapy waza wathatha inxaxheba kuvavanyo lweklinikhi lweeseli ze-NK zegazi lentambo.

Esi sigulana safumana unyango lokuqala ngoFebruwari 2021 kwaye okwesibini emva kweenyanga ezi-6. Kangangeentsuku ezi-4 ezilandelelanayo, kwenziwa i-intravenous infusion enye yemihla ngemihla kunye ne-immunophenotyping ngaphambi nasemva komjikelo ngamnye wonyango.

Emva kwekhosi yokuqala ye-immunotherapy kwiiseli ze-NK zegazi lentambo, isigulana safumana ukuxolelwa okuncinci. Amandla aso omzimba, ukutya, kunye nomgangatho wokulala konke kwakuphucukile.

Emva kwekhosi yesibini yonyango, umphandi wenze i-PET-CT scan. I-scan ibonise ukwehla kobukhulu be-hypermetabolic mass yesibeleko esifanelekileyo kunye nokwehla okukhulu kwi-metabolism yesibeleko kunye nomthamo xa kuthelekiswa nonyango lwangaphambi konyango. Nangona ubunzima bentloko ye-femoral ekunene kunye ne-metastasis yembambo ye-10 kunye ne-11 ekunene zingatshintshanga, i-metabolism ye-metastases yethambo yayiqhelekile. I-metastases ye-lymph node ezininzi entanyeni, kwi-mediastinum, kwi-retroperitoneum, nakwi-pelvis nazo zanyamalala.

Emva kweekhosi ezimbini, amanqaku emeko yomzimba ehla ukusuka kwi-3 ukuya kwi-1 kwaye umgangatho wobomi uphucuke kakhulu.