Isigaba somdlavuza we-endometrial IVB-04

Isiguli sasingowesifazane oneminyaka engu-55 ubudala, kanti i-histopathology ye-biopsy yaqinisekisa ukutholakala kwesigaba se-IVB somdlavuza we-endometrial esingahlukanisiwe kahle.

Ukwehluka okuphansi kanye nomdlavuza ophezulu. Isimila sakhe sase sikhule kakhulu futhi sasingenakukwazi ukususwa ngokuphelele ngokuhlinzwa. Ukuhlolwa okwengeziwe kubonise ukuthi iziguli zazinciphise isilinganiso sama-lymphocyte kanye nokubalwa kanye nomsebenzi wamaseli e-NK ophansi kakhulu. Engakwazi ukubekezelela imiphumela emibi, wayeka ukwelashwa ngamakhemikhali futhi wahlanganyela ekuhlolweni kwezokwelapha kwamaseli e-NK egazi lentambo.

Lesi siguli sathola ukwelashwa kokuqala ngoFebhuwari 2021 kanye nokwesibili ezinyangeni eziyi-6 kamuva. Izinsuku ezine zilandelana, kwenziwa ukumnika kanye ngosuku kanye ne-immunophenotyping ngaphambi nangemva komjikelezo ngamunye wokwelashwa.

Ngemva kwenkambo yokuqala yokwelashwa nge-immunotherapy kumaseli e-NK egazi lentambo, isiguli sathola ukuphulukiswa okuyingxenye. Amandla aso omzimba, isifiso sokudla, kanye nekhwalithi yokulala konke kwase kuthuthukile.

Ngemva kwenkambo yesibili yokwelashwa, umphenyi wenze i-PET-CT scan. I-scan ibonise ukwehla kobukhulu be-hypermetabolic mass yesibeletho kanye nokwehla okukhulu kwe-metabolism yesibeletho kanye nevolumu uma kuqhathaniswa nokwelashwa kwangaphambi kokwelashwa. Nakuba i-femoral head mass efanele kanye ne-10th kanye ne-11th rib metastasis kwesokudla kungashintshile, i-metabolism ye-bone metastases yayivamile. I-metastases ye-lymph node eminingi entanyeni, i-mediastinum, i-retroperitoneum, kanye ne-pelvis nayo yanyamalala.

Ngemva kwezifundo ezimbili, amaphuzu esimo somzimba ehla kusuka ku-3 kuya ku-1 futhi ikhwalithi yokuphila yathuthuka kakhulu.