Ka Moʻolelo o ka Mea Maʻi: Mai ka ʻIke AML-M2 a i kahi Freshman o ke Kulanui - He Huakaʻi ʻElima Makahiki i ka Hoʻōla ʻana
I ke kauwela o 2015, ua ʻike ʻia he keiki kāne 12 makahiki ʻo Mingming (ʻano ʻē) me ka leukemia myeloid acute (AML-M2). ʻO ka mea i manaʻo ʻia he manawa hopohopo ʻole ma ka papa ʻeono ua lilo ia i huakaʻi paʻakikī o nā lāʻau lapaʻau, nā noho haukapila, a me ka hoʻoikaika mau. I kēia lā, ʻelima mau makahiki ma hope o ke kāpili ʻana, ʻaʻole i hoʻokō wale ʻo Mingming i ke kala ʻana akā ua hoʻokō pū i kāna moeʻuhane o ke komo ʻana i ke kulanui.
He Hōʻailona Hoʻoweliweli a me ka ʻImi ʻana i ka Manaʻolana
ʻO nā hōʻailona mua o Mingming, me ka ʻeha o ka iwi a me ka palapū i ʻike ʻia, ua alakaʻi i ka ʻike weliweli o AML-M2. Ua hoʻomaka kona ʻohana, e noho ana ma kahi kalana liʻiliʻi ma Xinjiang, i kahi huakaʻi paʻakikī mai kekahi haukapila a i kekahi e ʻimi ana i ka lāʻau lapaʻau kūpono. Ua piha ke kaua me nā pilikia kino a me ka naʻau, ʻoiai ua hoʻopau nā pōʻaiapuni chemotherapy iā ia a me ka ʻuhane o kona ʻohana. ʻOiai ua loaʻa ka hoʻokuʻu morphological hapa, ua ʻike ʻia ka gene fusion AML1-ETO, e hōʻailona ana i kahi pane piha ʻole.
He Hoʻomaka Hou ma ka Halemai ʻo Lu Daopei
I Iune 2016, ua hōʻea ʻo Mingming a me kona ʻohana i ka Halemai ʻo Lu Daopei. Ma hope o nā loiloi piha, ua ʻōlelo aku ke kime lapaʻau, i alakaʻi ʻia e Kauka Zhou Jarui lāua ʻo Kauka Wang Jingyu, i kahi hoʻoili cell kumu hematopoietic haploidentical me ka hoʻohana ʻana i kona makuakāne ma ke ʻano he mea hāʻawi. ʻO ka mālama pono a me ka ʻike loea o ka kime hoʻoili i hoʻokomo i ka manaʻolana hou a me ke koa i loko o Mingming a me kona ʻohana.
He paʻakikī ke kaʻina hana hoʻoili. Ua kū ʻo Mingming i nā pilikia, me ka maʻi akepaʻa a me ka ʻili graft-versus-host (GVHD) a me ka maʻi cytomegalovirus (CMV). Eia nō naʻe, ua kōkua ka mālama ʻoihana a me ke aloha o ka hui iā ia e lanakila i kēia mau pilikia. I ka makahiki 2018, ua hōʻoia ʻia ka allogeneic chimerism ma 100%, a ua noho ka maʻi i ka hoʻomaha ʻana i ka wā o nā hahai ʻana.
Ua Hoʻokō ʻia kahi Moeʻuhane
I kēia manawa, ʻelima mau makahiki ma hope o ke kāpili ʻana, ke hoʻomau nei ke olakino o Mingming i ka holomua, a ua hoʻokō ʻo ia i kāna pahuhopu o ke hele ʻana i ke kulanui. I ka noʻonoʻo ʻana i kāna huakaʻi, hōʻike ʻo ia i ka mahalo nui i kona ʻohana, nā limahana lapaʻau i hoʻolaʻa ʻia ma ka Halemai ʻo Lu Daopei, a me ke kaiāulu ākea i kākoʻo iā ia. ʻO ka moʻolelo o Mingming kahi hōʻike i ke kūpaʻa a me ka mana o ka mālama olakino holomua i ka hoʻololi ʻana i nā ola.
He Leka o ka Manaʻolana
I ka poʻe e hakakā nei i nā maʻi like, kaʻana like ʻo Mingming:
"Mai makaʻu. E hoʻoikaika a neʻe i mua. ʻAʻole ʻoe hoʻokahi i kēia hakakā. Ma hope ou ʻaʻole wale kou ʻohana akā ʻo nā kauka lapaʻau he nui a me nā poʻe e mālama nui ana i kou ho'ōla ʻana. I ka hui pū ʻana, hiki iā kākou ke lanakila i ka pouli o ka maʻi a apo i ke kukui o ke ola."