Ukulimala kweMithambo yoMbono-02

Unyango lweeStem Cell kwiNzakalo yeMithambo yoMbono: Ummangaliso woKuphinda Ubone

Kwiteknoloji yezonyango ephucula ngokukhawuleza yanamhlanje, izifo ezininzi ezazikade zithathwa njengezinganyangekiyo ngoku zifumana ithemba elitsha. Namhlanje, sabelana ngebali elichukumisayo malunga nonyango lwe-mesenchymal stem cell (MSC) lokwenzakala kwemithambo-luvo, indlela yonyango evuselela ithemba lokubona kwizigulana ezininzi.

Ibali likaMnu. Zhang

UMnu. Zhang, oneminyaka engama-47 ubudala, ungunjineli ozinikeleyo. Nangona kunjalo, ubomi bakhe butshintshe kakhulu kwiinyanga ezine ezidlulileyo ngenxa yengozi enkulu yemoto. Kule ngozi, uMnu. Zhang wonzakele kakhulu kwi-optic nerve yakhe yasekunene, nto leyo eyabangela ukuba umbono wakhe uhle ngokukhawuleza, nto leyo eyabangela ukuba angaboni kakuhle. Nangona wayesebenzisa unyango lwendabuko ngee-steroids kunye namayeza e-neurotrophic, umbono wakhe awuzange uphucuke kangako. Le meko yamkhathaza kakhulu yena nosapho lwakhe.

Emva kwengcebiso yomhlobo, uMnu. Zhang wafunda ngonyango olutsha—unyango lwe-mesenchymal stem cell. Emva kokubonisana ngokucokisekileyo noogqirha abakhethekileyo nokuqonda ngokupheleleyo inkqubo yonyango, uMnu. Zhang wagqiba ekubeni azame le ndlela intsha.

Iiseli ze-stem zithathwe egazini le-umbilical cord lamavolontiya aphilileyo, ahlolwe ngokucokisekileyo kwaye andiswa kwinkcubeko ukuze abe namandla okuvuselela nokulungisa. Ezi seli ze-stem zifakwa ngokuchanekileyo kwiliso lasekunene likaMnu. Zhang ukuze kukhuthazwe ukuvuselelwa kwe-optic nerve eyonakeleyo.

Inkqubo yonyango yenziwe kwindawo engenazintsholongwane ukuqinisekisa ukhuseleko kunye nokuchaneka kuyo yonke inyathelo. Kwiveki yokuqala emva kotyando, uMnu. Zhang wafumana ukudumba okuncinci kunye nokungonwabi kwindawo efakwe kuyo inaliti, ngaphandle kwezinye iimpawu ezimbi. Nangona kunjalo, ngokumangalisayo, ekupheleni kwenyanga yokuqala emva kotyando, uMnu. Zhang waqala ukubona ukukhanya okuncinci kwaye wayekwazi ukubona ukukhanya okukhanyayo. Olu tshintsho lwamenza wanethemba ngekamva.

Kwiinyanga ezalandelayo, umbono kaMnu. Zhang waphucuka kancinci kancinci. Kwinyanga yesithathu, wayekwazi ukubona iintshukumo zezinto ezinkulu, kwaye uvavanyo lwe-VIS (VEP) lwabonisa ukubuyiselwa okukhulu komsebenzi wokuhambisa imithambo-luvo. Kwinyanga yesithandathu, umbono wakhe wasekunene wazinza malunga ne-0.15, okwamenza wakwazi ukwahlula iifonti ezinkulu kunye neemilo ezilula, nto leyo eyaphucula kakhulu umgangatho wobomi bakhe bemihla ngemihla.

Ukuchacha kukaMnu. Zhang akubonisi nje kuphela uloyiso lwezonyango zanamhlanje kodwa kukwangqina imizamo edibeneyo yabaphandi abaninzi bezonyango kunye namavolontiya. Iiseli ze-Mesenchymal stem, ngokukhupha izinto ezahlukeneyo zokukhula kunye nee-cytokines, zenze lula ukuvuselelwa kunye nokubuyiselwa kokusebenza kwe-optic nerve eyonakeleyo. Le ndlela yonyango ibonisa amandla amakhulu, inika ithemba kwizigulana ezininzi ezinjengoMnu. Zhang.