ʻEha o ke aʻalolo maka-02

ʻO ka Lapaʻau Stem Cell no ka ʻeha o ke aʻalolo Optic: He Hana Mana e Hoʻihoʻi Ana i ka ʻIke

I loko o ka ʻenehana lapaʻau e holomua wikiwiki nei i kēia lā, ua ʻike ʻia nā maʻi he nui i manaʻo ʻia he hiki ʻole ke mālama ʻia i kēia manawa he manaʻolana hou. I kēia lā, ke kaʻana like nei mākou i kahi moʻolelo hoʻopā e pili ana i ka lāʻau lapaʻau mesenchymal stem cell (MSC) no ka ʻeha o ke aʻalolo optic, kahi ʻano lapaʻau e lawe mai ana i ka manaʻolana hou o ka ʻike no nā maʻi he nui.

Ka Moʻolelo o Mr. Zhang

He ʻenekinia hoʻolaʻa ʻo Mr. Zhang, he 47 ona makahiki. Eia naʻe, ua loli nui kona ola i ʻehā mahina i hala aku nei ma muli o kahi ulia kaʻa koʻikoʻi. I loko o ka ulia, ua loaʻa iā Mr. Zhang kahi pōʻino nui i kona aʻalolo optic ʻākau, e hōʻemi wikiwiki ana i ka ʻike maka i ka ʻike māmā wale nō. ʻOiai ua hana ʻia nā lāʻau lapaʻau kuʻuna me nā steroids a me nā lāʻau neurotrophic, ʻaʻole i hōʻike iki ʻia kāna ʻike maka. Ua hoʻopilikia nui kēia kūlana iā ia a me kona ʻohana.

Ma muli o ka ʻōlelo aʻoaʻo a kekahi hoaaloha, ua aʻo ʻo Mr. Zhang e pili ana i kahi lāʻau lapaʻau e kū mai ana—ʻo ia hoʻi ka lāʻau lapaʻau mesenchymal stem cell. Ma hope o nā kūkākūkā kikoʻī me nā kauka kūikawā a me ka hoʻomaopopo piha ʻana i ke kaʻina hana lapaʻau, ua hoʻoholo ʻo Mr. Zhang e hoʻāʻo i kēia ʻano hana hou.

Ua lawe ʻia nā pūnaewele kumu mai ke koko umbilical o nā limahana manawaleʻa olakino, ua nānā pono ʻia a hoʻonui ʻia i loko o ka moʻomeheu e loaʻa nā mana hoʻōla hou a hoʻoponopono. Ma o ka hoʻokomo ʻana i loko o ka ʻōpū optic nerve, ua hāʻawi pololei ʻia kēia mau pūnaewele kumu i loko o ka maka ʻākau o Mr. Zhang e paipai i ka hana hou ʻana o ke aʻalolo optic i hōʻino ʻia.

Ua mālama ʻia ke kaʻina hana lapaʻau i loko o kahi ʻano maʻemaʻe e hōʻoia i ka palekana a me ka pololei i kēlā me kēia ʻanuʻu. I ka pule mua ma hope o ke ʻoki ʻana, ua ʻike wale ʻo Mr. Zhang i ka pehu iki a me ka ʻoluʻolu ʻole ma kahi i hoʻokomo ʻia ai, me ka ʻole o nā hōʻailona ʻino ʻē aʻe. Eia naʻe, he mea kupanaha, i ka hopena o ka mahina mua ma hope o ke ʻoki ʻana, ua hoʻomaka ʻo Mr. Zhang e ʻike i ka mālamalama palupalu a hiki ke ʻike i ka mālamalama ʻālohilohi. Ua hoʻopiha kēia hoʻololi iā ia me ka manaʻolana no ka wā e hiki mai ana.

I nā mahina ma hope mai, ua holomua mālie ka ʻike o Mr. Zhang. I ke kolu o ka mahina, ua hiki iā ia ke ʻike i nā neʻe ʻana o nā mea nui, a ua hōʻike nā hoʻokolohua visual evoked potential (VEP) i ka hoʻōla nui ʻana o ka hana hoʻokele aʻalolo optic. I ke ono o ka mahina, ua paʻa ka ʻike o kona maka ʻākau ma kahi o 0.15, e hiki ai iā ia ke hoʻokaʻawale i nā kinona nui a me nā ʻano maʻalahi, e hoʻomaikaʻi nui ana i kona ʻano o ke ola o kēlā me kēia lā.

ʻO ka ho'ōla ʻana o Mr. Zhang ʻaʻole ia he lanakila wale nō o ka lāʻau lapaʻau hou akā he hōʻike hoʻi i nā hana like ʻana o nā mea noiʻi lapaʻau he nui ʻole a me nā mea manawaleʻa. ʻO nā pūnaewele kumu mesenchymal, ma o ka hoʻokuʻu ʻana i nā mea ulu like ʻole a me nā cytokines, ua kōkua i ka hana hou ʻana a me ka hoʻōla ʻana i ka hana o ke aʻalolo optic i hōʻino ʻia. Hōʻike kēia ʻano lapaʻau i ka hiki nui loa, e hāʻawi ana i ka manaʻolana i nā maʻi he nui e like me Mr. Zhang.